SCHEMBL724546

SCHEMBL724546

CC(C)C[C@H](NC(=O)[C@@H](N)CC(C)C)C(=O)N(C(=O)OCc1ccccc1)[C@H](C=O)CC(C)C

nearest known ligand 0.46

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CTSK P43235 9/20 0.46
CTSB P07858 5/20 0.46
CTSL P07711 4/20 0.46
CTSS P25774 3/20 0.46
PSMB1 P20618 1/20 0.45
PSMB5 P28074 1/20 0.45
PSMB2 P49721 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2140167 0.93 CTSK (0.48) CTSKCTSBCTSLCTSSPSMB1
SCHEMBL6014225 0.91 CTSK (0.44) CTSKCTSBCTSLCTSSPSMB1
SCHEMBL1014662 0.88 CTSB (0.44) CTSKCTSBCTSLCTSSPSMB1
SCHEMBL26910148 0.85 CTSK (0.56) CTSKCTSBCTSLCTSSPSMB1
SCHEMBL19400126 0.85 CTSK (0.56) CTSKCTSBCTSLCTSSPSMB1
SCHEMBL28288627 0.85 CTSK (0.56) CTSKCTSBCTSLCTSSPSMB1
SCHEMBL28034519 0.83 CTSK (0.49) CTSKCTSBCTSLCTSS
SCHEMBL8586811 0.81 CTSB (0.47) CTSKCTSBCTSLCTSSPSMB1
SCHEMBL11209394 0.80 CTSK (0.58) CTSKCTSBCTSLCTSS
SCHEMBL27824395 0.80 CTSK (0.58) CTSKCTSBCTSLCTSS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 152 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3841097-B1 2,6-BIS(((1H-BENZO[D]IMIDAZOL-2-YL)THIO)METHYL)PYRIDINE AND N2,N6-DIBENZYLPYRIDINE-2,6-DICARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS PHOSPHOINOSITIDE 3-KINASE (PI3K) INHIBITORS FOR TREATING CANCER BIOMEDICAL RES FOUNDATION OF THE ACADEMY OF ATHENS BRFAA (GR) 2026-05-20 EP claimed
WO-2024118561-A2 DYSREGULATION OF NEUROPROTEASOMES BY APOE ISOFORMS DRIVES ENDOGENOUS TAU AGGREGATION THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2024-06-06 WO claimed
EP-4313144-A1 COMBINATIONS COMPRISING ANTI-TM4SF1 ANTIBODIES AND IMMUNOTHERAPEUTIC AGENTS AND METHODS OF USING THE SAME Angiex, Inc. (US) 2024-02-07 EP claimed
US-20230293713-A1 ANTI-TM4SF1 ANTIBODY DRUG CONJUGATES AND METHODS OF USING SAME ANGIEX, INC. 2023-09-21 US claimed
WO-2022204565-A1 COMBINATIONS COMPRISING ANTI-TM4SF1 ANTIBODIES AND IMMUNOTHERAPEUTIC AGENTS AND METHODS OF USING THE SAME ANGIEX, INC. (US) 2022-09-29 WO claimed
EP-3319965-B1 NOVEL COMPOUNDS FOR USE IN TREATING OR PREVENTING CANCEROUS DISEASES BIOMEDICAL RES FOUNDATION OF THE ACADEMY OF ATHENS (GR) 2022-05-04 EP claimed
WO-2021222783-A1 ANTI-TM4SF1 ANTIBODY DRUG CONJUGATES AND METHODS OF USING SAME ANGIEX, INC. (US) 2021-11-04 WO claimed
US-20210246120-A1 METHOD OF PREPARATION AND USE OF PHOSPHOINOSITIDE 3-KINASE INHIBITORS IN TREATING CANCER FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS (FORTH) (GR) 2021-08-12 US claimed
EP-3841097-A1 2,6-BIS(((1H-BENZO[D]IMIDAZOL-2-YL)THIO)METHYL)PYRIDINE AND N2,N6-DIBENZYLPYRIDINE-2,6-DICARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS PHOSPHOINOSITIDE 3-KINASE (PI3K) INHIBITORS FOR TREATING CANCER Biomedical Research Foundation of the Academy of Athens (GR) 2021-06-30 EP claimed
WO-2020039097-A1 2,6-BIS(((1H-BENZO[D]IMIDAZOL-2-YL)THIO)METHYL)PYRIDINE AND N2,N6-DIBENZYLPYRIDINE-2,6-DICARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS PHOSPHOINOSITIDE 3-KINASE (PI3K) INHIBITORS FOR TREATING CANCER BIOMEDICAL RESEARCH FOUNDATION OF THE ACADEMY OF ATHENS (BRFAA) (GR) 2020-02-27 WO claimed
EP-2078201-A2 DENGUE DIAGNOSIS AND TREATMENT Agency for Science, Technology and Research (SG) 2009-07-15 EP claimed
US-20080248097-A1 POLYMERIC MICELLES FOR COMBINATION DRUG DELIVERY WISCONSIN ALUMNI RESEARCH FOUNDATION 2008-10-09 US claimed
WO-2008106129-A2 POLYMERIC MICELLES FOR COMBINATION DRUG DELIVERY WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2008-09-04 WO claimed
WO-2008041953-A2 DENGUE DIAGNOSIS AND TREATMENT AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2008-04-10 WO claimed
US-20080045495-A1 Treatment of Patients with Cystic Disease by Alteration of Fibrocystin Proteolysis BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2008-02-21 US claimed
US-7238659-B2 Reducing axon degeneration with proteasome inhibitors CHILDREN'S MEDICAL CENTER CORPORATION (US) 2007-07-03 US claimed
US-20060074028-A1 Reducing axon degeneration with proteasome inhibitors CHILDREN'S MEDICAL CENTER CORP 2006-04-06 US claimed
US-7012063-B2 Reducing axon degeneration with proteasome inhibitors CHILDREN'S MEDICAL CENTER CORPORATION (US) 2006-03-14 US claimed
WO-2005014783-A2 REDUCING AXON DEGENERATION WITH PROTEASOME INHIBITORS CHILDREN'S MEDICAL CENTER CORPORATION (US) 2005-02-17 WO claimed
US-20040254118-A1 Reducing axon degeneration with proteasome inhibitors CHILDREN'S MEDICAL CENTER CORPORATION 2004-12-16 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210246120-A1 METHOD OF PREPARATION AND USE OF PHOSPHOINOSITIDE 3-KINASE INHIBITORS IN TREATING CANCER PIK3R3, PIK3CA, PIK3C2A CTSK 4085/4885CTSB 4058/4885CTSL 4307/4885
US-20080248097-A1 POLYMERIC MICELLES FOR COMBINATION DRUG DELIVERY MCL1, NUP205, ABCB1 CTSK 3999/4885CTSB 1020/4885CTSL 3552/4885
US-20080045495-A1 Treatment of Patients with Cystic Disease by Alteration of Fibrocystin Proteolysis PKD1, CAPN1, PKD2 CTSK 60/4885CTSB 40/4885CTSL 70/4885
US-20230293713-A1 ANTI-TM4SF1 ANTIBODY DRUG CONJUGATES AND METHODS OF USING SAME TM9SF4, TM9SF2, TM9SF3 CTSK 1456/4885CTSB 2080/4885CTSL 1614/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.