SCHEMBL7246182

SCHEMBL7246182

CC(C)(C)C(O)[C@H]1O[C@](n2cnc3c(NC(=O)c4ccccc4)ncnc32)([SiH](c2ccccc2)c2ccccc2)[C@H](OCCON2C(=O)c3ccccc3C2=O)[C@@H]1O

nearest known ligand 0.37

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
PRMT6 Q96LA8 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7065334 0.77 P2RY12 (0.35) PRMT6
SCHEMBL7063493 0.77 P2RY12 (0.34) PRMT6
SCHEMBL7251726 0.75 P2RY12 (0.33) PRMT6
SCHEMBL7251215 0.74 P2RY12 (0.34) PRMT6
SCHEMBL7246175 0.72 PRMT6 (0.43) PRMT6
SCHEMBL7863923 0.71 PRMT6 (0.35) PRMT6
SCHEMBL7251671 0.69 P2RY12 (0.34) PRMT6
SCHEMBL7246178 0.68 P2RY12 (0.44) PRMT6
SCHEMBL6402247 0.68 ADORA1 (0.39)
SCHEMBL8923627 0.66 PRMT6 (0.36) PRMT6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6639062-B2 Oligonucleotides which elicit ribonuclease for cleavage in complementary nucleic acid strand, having increased binding affinity/nuclease resistance; for medical diagnosis, gene therapy ISIS PHARMACEUTICALS, INC. 2003-10-28 US disclosed
US-6420549-B1 NUCLEOTIDE SEQUENCES FOR USE AS TOOLS IN GENETIC ENGINEERING AND CONTROLLING TRANSLATION ISIS PHARMACEUTICALS, INC. 2002-07-16 US disclosed