Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | TAS2R14 | Q9NYV8 | 3/20 | 0.47 |
| ▸ | MMP1 | P03956 | 7/20 | 0.47 |
| ▸ | MMP3 | P08254 | 7/20 | 0.47 |
| ▸ | MMP9 | P14780 | 6/20 | 0.47 |
| ▸ | MMP7 | P09237 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7246571 | 1.00 | LMNA (0.55) | LMNAKDM4EALDH1A1TSHRRECQL | |
| SCHEMBL7244524 | 0.89 | MMP1 (0.57) | MMP1MMP3MMP9MMP7MMP2 | |
| SCHEMBL7248829 | 0.84 | MMP3 (0.50) | MMP1MMP3MMP9MMP7MMP2 | |
| SCHEMBL8517198 | 0.84 | MMP3 (0.50) | MMP1MMP3MMP9MMP7MMP2 | |
| SCHEMBL7248830 | 0.84 | MMP3 (0.50) | MMP1MMP3MMP9MMP7MMP2 | |
| SCHEMBL7249697 | 0.83 | MMP1 (0.50) | LMNAKDM4EALDH1A1TSHRRECQL | |
| SCHEMBL7249691 | 0.83 | MMP1 (0.50) | LMNAKDM4EALDH1A1TSHRRECQL | |
| SCHEMBL6076031 | 0.78 | MMP3 (0.47) | TAS2R14MMP1MMP3MMP9MMP7 | |
| SCHEMBL6076042 | 0.76 | CA12 (0.53) | LMNAKDM4EALDH1A1TSHRRECQL | |
| SCHEMBL7424316 | 0.76 | MMP3 (0.48) | MMP1MMP3MMP9MMP7MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6509337-B1 | A method of treating a mammalian disease condition mediated by metalloproteinase activity which comprises administering to a mammal in need thereof a therapeutically effective amount of a compound as defined in claim 1 or a pharmaceutically | PFIZER INC. | 2003-01-21 | — | — | US | disclosed |
| EP-0821671-B1 | ARYLSULFONYL HYDROXAMIC ACID DERIVATIVES AS MMP AND TNF INHIBITORS | PFIZER (US) | 2000-12-27 | — | — | EP | disclosed |
| US-5861510-A | Arylsulfonyl hydroxamic acid derivatives as MMP and TNF inhibitors | PFIZER INC (US) | 1999-01-19 | — | — | US | disclosed |
| EP-0821671-A1 | ARYLSULFONYL HYDROXAMIC ACID DERIVATIVES AS MMP AND TNF INHIBITORS | PFIZER INC. (US) | 1998-02-04 | — | — | EP | disclosed |
| WO-1996033172-A1 | ARYLSULFONYL HYDROXAMIC ACID DERIVATIVES AS MMP AND TNF INHIBITORS | PFIZER INC. (US) | 1996-10-24 | — | — | WO | disclosed |