Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 16/20 | 0.50 |
| ▸ | MMP3 | P08254 | 14/20 | 0.50 |
| ▸ | MMP9 | P14780 | 13/20 | 0.50 |
| ▸ | MMP2 | P08253 | 13/20 | 0.50 |
| ▸ | MMP13 | P45452 | 10/20 | 0.50 |
| ▸ | MMP7 | P09237 | 7/20 | 0.49 |
| ▸ | MMP8 | P22894 | 4/20 | 0.49 |
| ▸ | MMP12 | P39900 | 1/20 | 0.47 |
| ▸ | MMP14 | P50281 | 1/20 | 0.47 |
| ▸ | MMP15 | P51511 | 1/20 | 0.47 |
| ▸ | MMP16 | P51512 | 1/20 | 0.47 |
| ▸ | MMP26 | Q9NRE1 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7249697 | 1.00 | MMP1 (0.50) | MMP1MMP3MMP9MMP2MMP13 | |
| SCHEMBL7244524 | 0.85 | MMP1 (0.57) | MMP1MMP3MMP9MMP2MMP13 | |
| SCHEMBL7246571 | 0.83 | LMNA (0.55) | MMP1MMP3MMP9MMP2MMP13 | |
| SCHEMBL7246567 | 0.83 | LMNA (0.55) | MMP1MMP3MMP9MMP2MMP13 | |
| SCHEMBL5346807 | 0.79 | MMP9 (0.68) | MMP1MMP3MMP9MMP2MMP13 | |
| SCHEMBL5342854 | 0.79 | MMP9 (0.68) | MMP1MMP3MMP9MMP2MMP13 | |
| SCHEMBL7054410 | 0.79 | MMP1 (0.57) | MMP1MMP3MMP9MMP2MMP13 | |
| SCHEMBL14501347 | 0.74 | MMP3 (0.71) | MMP1MMP3MMP9MMP2MMP13 | |
| SCHEMBL5339997 | 0.74 | MMP3 (0.71) | MMP1MMP3MMP9MMP2MMP13 | |
| SCHEMBL5335517 | 0.74 | MMP3 (0.71) | MMP1MMP3MMP9MMP2MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6509337-B1 | A method of treating a mammalian disease condition mediated by metalloproteinase activity which comprises administering to a mammal in need thereof a therapeutically effective amount of a compound as defined in claim 1 or a pharmaceutically | PFIZER INC. | 2003-01-21 | — | — | US | disclosed |
| EP-0821671-B1 | ARYLSULFONYL HYDROXAMIC ACID DERIVATIVES AS MMP AND TNF INHIBITORS | PFIZER (US) | 2000-12-27 | — | — | EP | disclosed |
| EP-0821671-A1 | ARYLSULFONYL HYDROXAMIC ACID DERIVATIVES AS MMP AND TNF INHIBITORS | PFIZER INC. (US) | 1998-02-04 | — | — | EP | disclosed |
| WO-1996033172-A1 | ARYLSULFONYL HYDROXAMIC ACID DERIVATIVES AS MMP AND TNF INHIBITORS | PFIZER INC. (US) | 1996-10-24 | — | — | WO | disclosed |