Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 5/20 | 0.34 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.34 |
| ▸ | MRGPRX1 | Q96LB2 | 6/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7097637 | 0.88 | BRD4 (0.32) | BRAFPSIP1MRGPRX1CYP2C9PDE10A | |
| SCHEMBL7103450 | 0.86 | BRD4 (0.31) | PDE10AHTT | |
| SCHEMBL7248504 | 0.81 | PSIP1 (0.37) | BRAFPSIP1MRGPRX1CYP2C9JAK2 | |
| SCHEMBL7248295 | 0.81 | PGR (0.37) | BRAFPSIP1HTTMAPK14LMNA | |
| SCHEMBL7248382 | 0.81 | NR3C1 (0.41) | PSIP1MRGPRX1CYP2C9PDE10AHTT | |
| SCHEMBL7248995 | 0.79 | BRD4 (0.40) | PSIP1CYP2C9PDE10AJAK2JAK1 | |
| SCHEMBL7101637 | 0.77 | NR3C1 (0.39) | PDE10A | |
| SCHEMBL7103402 | 0.75 | MRGPRX1 (0.34) | BRAFMRGPRX1PDE10AJAK2JAK1 | |
| SCHEMBL7098136 | 0.75 | PSIP1 (0.43) | BRAFPSIP1MRGPRX1JAK2JAK1 | |
| SCHEMBL7248142 | 0.74 | MRGPRX1 (0.35) | BRAFPSIP1MRGPRX1JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6503935-B1 | Treating urinary incontinence or retrograde ejaculation | ABBOTT LABORATORIES | 2003-01-07 | — | — | US | disclosed |
| EP-1102754-A1 | IMIDAZOLES AND RELATED COMPOUNDS AS ALPHA-1A AGONISTS | ABBOTT LABORATORIES (US) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000007997-A1 | IMIDAZOLES AND RELATED COMPOUNDS AS α1A AGONISTS | ABBOTT LABORATORIES (US) | 2000-02-17 | — | — | WO | disclosed |