Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSIP1 | O75475 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 3/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 5/20 | 0.31 |
| ▸ | JAK2 | O60674 | 2/20 | 0.31 |
| ▸ | TYK2 | P29597 | 2/20 | 0.31 |
| ▸ | JAK3 | P52333 | 2/20 | 0.31 |
| ▸ | PGR | P06401 | 2/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.31 |
| ▸ | FEN1 | P39748 | 2/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7098136 | 0.84 | PSIP1 (0.43) | PSIP1BRAFJAK1JAK2TYK2 | |
| SCHEMBL7248476 | 0.81 | BRAF (0.34) | PSIP1BRAFCYP2C9JAK1JAK2 | |
| SCHEMBL7105179 | 0.81 | HPGD (0.39) | PSIP1JAK1JAK2TYK2JAK3 | |
| SCHEMBL7248295 | 0.79 | PGR (0.37) | PSIP1BRAFPGRBRD4ADRA2A | |
| SCHEMBL7097637 | 0.78 | BRD4 (0.32) | PSIP1BRAFCYP2C9BRD4MRGPRX1 | |
| SCHEMBL7097248 | 0.77 | S100A9 (0.37) | PSIP1JAK1JAK2TYK2JAK3 | |
| SCHEMBL7253191 | 0.77 | PSIP1 (0.35) | PSIP1BRAFJAK1JAK2TYK2 | |
| SCHEMBL7103450 | 0.76 | BRD4 (0.31) | BRD4 | |
| SCHEMBL7248995 | 0.74 | BRD4 (0.40) | PSIP1CYP2C9JAK1JAK2TYK2 | |
| SCHEMBL7248382 | 0.73 | NR3C1 (0.41) | PSIP1CYP2C9ADRA2AADRA1AMRGPRX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6503935-B1 | Treating urinary incontinence or retrograde ejaculation | ABBOTT LABORATORIES | 2003-01-07 | — | — | US | disclosed |
| EP-1102754-A1 | IMIDAZOLES AND RELATED COMPOUNDS AS ALPHA-1A AGONISTS | ABBOTT LABORATORIES (US) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000007997-A1 | IMIDAZOLES AND RELATED COMPOUNDS AS α1A AGONISTS | ABBOTT LABORATORIES (US) | 2000-02-17 | — | — | WO | disclosed |