Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.51 |
| ▸ | CCKBR | P32239 | 2/20 | 0.50 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.50 |
| ▸ | PDE5A | O76074 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL274285 | 0.87 | KDM4E (0.54) | SIRT1KDM4EHSD17B10HTTMAPKAPK2 | |
| SCHEMBL279185 | 0.86 | SIRT1 (0.53) | SIRT1KDM4EHSD17B10TSHRHTT | |
| SCHEMBL10278388 | 0.84 | MAPKAPK2 (0.63) | SIRT1KDM4ETSHRMAPKAPK2SIRT2 | |
| SCHEMBL11393500 | 0.83 | MAPT (0.57) | SIRT1KDM4EHSD17B10TSHRHTT | |
| SCHEMBL275311 | 0.83 | SIRT1 (0.71) | SIRT1KDM4EMAPKAPK2SIRT2CYP2D6 | |
| SCHEMBL11496260 | 0.82 | CYP19A1 (0.48) | SIRT1KDM4EHSD17B10MAPKAPK2SIRT2 | |
| SCHEMBL10042239 | 0.81 | KDM4E (0.66) | SIRT1KDM4EHSD17B10TSHRHTT | |
| SCHEMBL26805917 | 0.81 | SIRT1 (0.64) | SIRT1KDM4EHSD17B10TSHRHTT | |
| SCHEMBL1491406 | 0.80 | MAPKAPK2 (0.71) | KDM4EHSD17B10TSHRHTTMAPKAPK2 | |
| Hydrochloric Acid SCHEMBL28201946 | 0.79 | MAPKAPK2 (0.70) | KDM4EHSD17B10TSHRHTTMAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12116372-B1 | Process for preparing methyl 3-bromo-2-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)propanoate | BOULANGER WILLIAM ALLEN (US) | 2024-10-15 | — | — | US | disclosed |
| US-20240140956-A1 | Novel Pharmaceutical Intermediates and Methods for Preparing the Same | BOULANGER WILLIAM ALLEN (US) | 2024-05-02 | — | — | US | disclosed |
| US-11827643-B2 | Pharmaceutical intermediates and methods for preparing the same | OBITER RESEARCH, LLC (US) | 2023-11-28 | — | — | US | disclosed |
| US-11827643-B2 | Pharmaceutical intermediates and methods for preparing the same | OBITER RESEARCH, LLC (US) | 2023-11-28 | — | — | US | disclosed |
| US-20210115056-A1 | Pharmaceutical Intermediates and Methods for Preparing the Same | BOULANGER, WILLIAM ALLEN | 2021-04-22 | — | — | US | disclosed |
| US-10906912-B2 | Pharmaceutical intermediates and methods for preparing the same | KING T, LLC (US) | 2021-02-02 | — | — | US | disclosed |
| US-20190276464-A1 | Novel Pharmaceutical Intermediates and Methods for Preparing the Same | BOULANGER WILLIAM ALLEN (US) | 2019-09-12 | — | — | US | disclosed |
| US-9399642-B2 | Pharmaceutical intermediates and methods for preparing the same | BOULANGER, WILLIAM ALLEN | 2016-07-26 | — | — | US | disclosed |
| US-9399643-B2 | Pharmaceutical intermediates and methods for preparing the same | BOULANGER, WILLIAM ALLEN | 2016-07-26 | — | — | US | disclosed |
| US-20140213782-A1 | Novel Pharmaceutical Intermediates and Methods for Preparing the Same | BOULANGER, WILLIAM ALLEN | 2014-07-31 | — | — | US | disclosed |
| US-20140213797-A1 | Novel Pharmaceutical Intermediates and Methods for Preparing the Same | BOULANGER, WILLIAM ALLEN | 2014-07-31 | — | — | US | disclosed |
| US-20130178618-A1 | NOVEL PHARMACEUTICAL INTERMEDIATES AND METHODS FOR PREPARING THE SAME | KING T, LLC | 2013-07-11 | — | — | US | disclosed |
| US-20030095958-A1 | Inhibitors of bace | VERTEX PHARMACEUTICALS INCORPORATED | 2003-05-22 | — | — | US | disclosed |
| US-5095109-A | Antitumor | UNIVERSITY OF VERMONT (US) | 1992-03-10 | — | — | US | disclosed |
| WO-1990015061-A1 | NOVEL ALKALOIDS | THE UNIVERSITY OF VERMONT AND STATE AGRICULTURAL COLLEGE (US) | 1990-12-13 | — | — | WO | disclosed |
| US-4935509-A | ANTITUMOR AGENTS | UNIVERSITY OF VERMONT (US) | 1990-06-19 | — | — | US | disclosed |
| US-4897477-A | ANTITUMOR ALKALOIDS | UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE (US) | 1990-01-30 | — | — | US | disclosed |
| US-4841045-A | ANTITUMOR AGENTS | UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE (US) | 1989-06-20 | — | — | US | disclosed |
| EP-0215058-A1 | SYNTHESIS OF VINBLASTINE AND VINCRISTINE TYPE COMPOUNDS | THE UNIVERSITY OF VERMONT AND STATE AGRICULTURAL COLLEGE (US) | 1987-03-25 | — | — | EP | disclosed |
| WO-1986005491-A1 | SYNTHESIS OF VINBLASTINE AND VINCRISTINE TYPE COMPOUNDS | THE UNIVERSITY OF VERMONT AND STATE AGRICULTURAL C (US) | 1986-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030095958-A1 | Inhibitors of bace | BACE2, BACE1, APP | SIRT1 3077/4885KDM4E 1717/4885HSD17B10 2068/4885 |
| US-20140213797-A1 | Novel Pharmaceutical Intermediates and Methods for Preparing the Same | CYP3A7, CYP2C8, CNR2 | SIRT1 690/4885KDM4E 2209/4885HSD17B10 478/4885 |
| US-20190276464-A1 | Novel Pharmaceutical Intermediates and Methods for Preparing the Same | CYP3A7, CYP2C8, CNR2 | SIRT1 690/4885KDM4E 2209/4885HSD17B10 478/4885 |
| US-20210115056-A1 | Pharmaceutical Intermediates and Methods for Preparing the Same | CYP3A7, CYP2C8, CYP2C19 | SIRT1 797/4885KDM4E 1668/4885HSD17B10 588/4885 |
| US-12116372-B1 | Process for preparing methyl 3-bromo-2-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)propanoate | TET3, HTR3A, KMO | SIRT1 3372/4885KDM4E 129/4885HSD17B10 1693/4885 |
| US-20130178618-A1 | NOVEL PHARMACEUTICAL INTERMEDIATES AND METHODS FOR PREPARING THE SAME | CYP3A7, CYP2C8, CNR2 | SIRT1 690/4885KDM4E 2209/4885HSD17B10 478/4885 |
| US-10906912-B2 | Pharmaceutical intermediates and methods for preparing the same | CYP3A7, CYP2C8, CYP2C19 | SIRT1 797/4885KDM4E 1668/4885HSD17B10 588/4885 |
| US-20140213782-A1 | Novel Pharmaceutical Intermediates and Methods for Preparing the Same | CYP3A7, CYP2C8, CNR2 | SIRT1 690/4885KDM4E 2209/4885HSD17B10 478/4885 |
| US-11827643-B2 | Pharmaceutical intermediates and methods for preparing the same | CYP3A7, CYP2C8, CYP2C19 | SIRT1 797/4885KDM4E 1668/4885HSD17B10 588/4885 |
| US-20240140956-A1 | Novel Pharmaceutical Intermediates and Methods for Preparing the Same | CYP3A7, CYP2C8, CNR2 | SIRT1 690/4885KDM4E 2209/4885HSD17B10 478/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.