Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7244783 | 0.85 | POLB (0.55) | GAAPOLBDRD2DRD4KMT2A | |
| SCHEMBL4992588 | 0.78 | HTT (0.58) | HTTNPSR1GAAGPR55LMNA | |
| SCHEMBL7247950 | 0.77 | ADRA2A (0.44) | HTTPOLBDRD2DRD4KMT2A | |
| SCHEMBL7246923 | 0.76 | ADRA2B (0.40) | HTTNPSR1LMNAPOLBDRD2 | |
| SCHEMBL7251023 | 0.76 | LMNA (0.46) | HTTGAALMNATP53POLB | |
| SCHEMBL6300505 | 0.76 | POLB (0.51) | HTTNPSR1GAAGPR55LMNA | |
| SCHEMBL7242574 | 0.75 | KMT2A (0.59) | NPSR1GAATP53POLBDRD2 | |
| SCHEMBL7244603 | 0.75 | SIRT2 (0.44) | HTTNPSR1GAAPOLBKMT2A | |
| SCHEMBL30489340 | 0.73 | DRD2 (0.51) | HTTNPSR1GAAGPR55LMNA | |
| SCHEMBL7242765 | 0.72 | GSK3A (0.49) | HTTGAAPOLBDRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6632811-B2 | Administering cycloalkyl, lactam, lactone compounds for for inhibiting beta -amyloid peptide release and/or its synthesis in a cell | ATHENA NEUROSCIENCES, INC. | 2003-10-14 | — | — | US | disclosed |