Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 3/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.37 |
| ▸ | HTR7 | P34969 | 3/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | NCF1 | P14598 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6629232 | 0.78 | ADRB1 (0.53) | ADRB1HTR1AHTR3AHTR7NCF1 | |
| SCHEMBL7242525 | 0.78 | ADRB1 (0.53) | ADRB1HTR1AHTR3AHTR7NCF1 | |
| SCHEMBL7242984 | 0.71 | HTT (0.49) | ADRB1ADRB2HTR1AHTR3AHTR7 | |
| SCHEMBL2276545 | 0.67 | ADRB2 (0.55) | ADRB1ADRB2HTR1AHTR3ANCF1 | |
| SCHEMBL443520 | 0.67 | HTR3A (0.51) | ADRB1ADRB2HTR1AHTR3AHTR7 | |
| SCHEMBL6627622 | 0.67 | ALDH1A1 (0.68) | ADRB1ADRB2HTR1AHTR3ANCF1 | |
| SCHEMBL19403739 | 0.67 | HTR3A (0.55) | ADRB1ADRB2HTR1AHTR3AHTR7 | |
| SCHEMBL255333 | 0.67 | ADRB1 (0.65) | ADRB1ADRB2HTR1AHTR3AHTR7 | |
| SCHEMBL5252902 | 0.67 | MAPT (0.52) | ADRB1ADRB2HTR3ANCF1EPHX2 | |
| SCHEMBL7248900 | 0.66 | ADRB1 (0.37) | ADRB1HTR1AHTR3AAKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030095958-A1 | Inhibitors of bace | VERTEX PHARMACEUTICALS INCORPORATED | 2003-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030095958-A1 | Inhibitors of bace | BACE2, BACE1, APP | ADRB1 3834/4885ADRB2 4466/4885HTR1A 4154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.