Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.37 |
| ▸ | CA2 | P00918 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA3 | P07451 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA6 | P23280 | 1/20 | 0.34 |
| ▸ | CA5A | P35218 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10055326 | 0.95 | ALDH1A1 (0.41) | MAPK1POLBSMN1; SMN2ALDH1A1CA1 | |
| SCHEMBL10077809 | 0.84 | CA1 (0.41) | MAPK1POLBSMN1; SMN2ALDH1A1CA1 | |
| SCHEMBL10080126 | 0.82 | PLAU (0.32) | — | |
| SCHEMBL10055204 | 0.77 | METAP2 (0.31) | SMN1; SMN2ALDH1A1CA1CA2CA12 | |
| SCHEMBL10080127 | 0.77 | PLAU (0.33) | — | |
| SCHEMBL726171 | 0.67 | PTPN11 (0.42) | CA1CA2CYP2C19CA12CA9 | |
| SCHEMBL18880195 | 0.64 | MEN1 (0.46) | MAPK1POLBSMN1; SMN2 | |
| SCHEMBL10604597 | 0.63 | PRMT1 (0.55) | MAPK1LMNAKDM4EEPHX2PRMT1 | |
| SCHEMBL11067650 | 0.63 | PRMT1 (0.55) | MAPK1ALDH1A1LMNAKDM4EEPHX2 | |
| SCHEMBL9473225 | 0.63 | PRMT1 (0.55) | MAPK1LMNAKDM4EEPHX2PRMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9702001-B2 | Scaffold-based polymerase enzyme substrates | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2017-07-11 | — | — | US | disclosed |
| US-9702001-B2 | Scaffold-based polymerase enzyme substrates | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2017-07-11 | — | — | US | disclosed |
| US-20150307933-A1 | SCAFFOLD-BASED POLYMERASE ENZYME SUBSTRATES | PACIFIC BIOSCIENCES CALIFORNIA (US) | 2015-10-29 | — | — | US | disclosed |
| US-20150307933-A1 | SCAFFOLD-BASED POLYMERASE ENZYME SUBSTRATES | PACIFIC BIOSCIENCES CALIFORNIA (US) | 2015-10-29 | — | — | US | disclosed |
| US-8906612-B2 | Scaffold-based polymerase enzyme substrates | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| US-8906612-B2 | Scaffold-based polymerase enzyme substrates | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| WO-2012027625-A9 | SCAFFOLD-BASED POLYMERASE ENZYME SUBSTRATES | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2012-08-02 | — | — | WO | disclosed |
| US-20120077189-A1 | SCAFFOLD-BASED POLYMERASE ENZYME SUBSTRATES | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2012-03-29 | — | — | US | disclosed |
| US-20120077189-A1 | SCAFFOLD-BASED POLYMERASE ENZYME SUBSTRATES | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2012-03-29 | — | — | US | disclosed |
| WO-2012027625-A2 | SCAFFOLD-BASED POLYMERASE ENZYME SUBSTRATES | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2012-03-01 | — | — | WO | disclosed |
| WO-2012027625-A2 | SCAFFOLD-BASED POLYMERASE ENZYME SUBSTRATES | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2012-03-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077189-A1 | SCAFFOLD-BASED POLYMERASE ENZYME SUBSTRATES | POLM, RNGTT, POLR1G | MAPK1 3063/4885POLB 12/4885SMN1; SMN2 2719/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.