Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | TYK2 | P29597 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7250891 | 0.99 | L3MBTL1 (0.42) | F2L3MBTL1HDAC1HDAC8KDM4E | |
| SCHEMBL7243857 | 0.85 | F2 (0.54) | F2HDAC1HDAC8KDM4EHSD17B10 | |
| SCHEMBL7253523 | 0.85 | F2 (0.47) | F2HDAC1HDAC8GAAHDAC6 | |
| SCHEMBL7250212 | 0.83 | F2 (0.45) | F2L3MBTL1HDAC1HDAC8KDM4E | |
| SCHEMBL7250244 | 0.82 | HTR2C (0.45) | F2HDAC1HDAC8HDAC6POLB | |
| SCHEMBL7249842 | 0.82 | F2 (0.43) | F2HDAC1HDAC8HDAC6HTR2C | |
| SCHEMBL7252575 | 0.81 | THRB (0.44) | F2HDAC1HDAC8HCAR3HDAC6 | |
| SCHEMBL7248203 | 0.80 | F2 (0.42) | F2HDAC1HDAC8KDM4EHSD17B10 | |
| SCHEMBL7249812 | 0.80 | PPARG (0.42) | F2HDAC1HDAC8HDAC6HTR2C | |
| SCHEMBL7249727 | 0.80 | F2 (0.41) | F2HDAC1HDAC8HDAC6HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6512000-B1 | Aminocarbonyl- substituted benzimidazole derivatives for the treatment of diseases in which inhibition of tryptase is of therapeutic such as for treating an inflammatory or allergic disease | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-01-28 | — | — | US | disclosed |