Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | GLP1R | P43220 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.39 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7250650 | 0.88 | GLP1R (0.48) | F2HDAC1HDAC8HTR2CHDAC6 | |
| SCHEMBL7250212 | 0.86 | F2 (0.45) | F2HDAC1HDAC8HTR2CHDAC6 | |
| SCHEMBL7243857 | 0.86 | F2 (0.54) | F2HDAC1HDAC8HDAC6SMN1; SMN2 | |
| SCHEMBL7250244 | 0.86 | HTR2C (0.45) | F2HDAC1HDAC8HTR2CHDAC6 | |
| SCHEMBL7256417 | 0.85 | F2 (0.43) | F2HDAC1HDAC8HTR2CHDAC6 | |
| SCHEMBL7249842 | 0.84 | F2 (0.43) | F2HDAC1HDAC8HTR2CHDAC6 | |
| SCHEMBL7250891 | 0.84 | L3MBTL1 (0.42) | F2HDAC1HDAC8HTR2CHDAC6 | |
| SCHEMBL7248203 | 0.83 | F2 (0.42) | F2HDAC1HDAC8HTR2CHDAC6 | |
| SCHEMBL7252575 | 0.83 | THRB (0.44) | F2HDAC1HDAC8HTR2CHDAC6 | |
| SCHEMBL7249812 | 0.82 | PPARG (0.42) | F2HDAC1HDAC8HTR2CHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6512000-B1 | Aminocarbonyl- substituted benzimidazole derivatives for the treatment of diseases in which inhibition of tryptase is of therapeutic such as for treating an inflammatory or allergic disease | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-01-28 | — | — | US | disclosed |