Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSIP1 | O75475 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | MRGPRX1 | Q96LB2 | 2/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
| ▸ | PGR | P06401 | 2/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7248142 | 0.82 | MRGPRX1 (0.35) | PSIP1ALOX5APFEN1BRAFMRGPRX1 | |
| SCHEMBL7251725 | 0.81 | SMN1; SMN2 (0.38) | PSIP1MRGPRX1JAK2JAK1TYK2 | |
| SCHEMBL7247371 | 0.80 | PGR (0.35) | PSIP1BRAFPGRBRD4 | |
| SCHEMBL7248504 | 0.77 | PSIP1 (0.37) | PSIP1ALOX5APFEN1BRAFMRGPRX1 | |
| SCHEMBL7254245 | 0.75 | NR3C1 (0.40) | PSIP1MRGPRX1 | |
| SCHEMBL7251929 | 0.75 | BRD4 (0.41) | JAK2JAK1TYK2JAK3BRD4 | |
| SCHEMBL7254725 | 0.74 | HPGD (0.32) | PSIP1BRAFJAK1BRD4 | |
| SCHEMBL7099135 | 0.73 | ADRA1A (0.43) | BRD4 | |
| SCHEMBL7254169 | 0.72 | — | — | |
| SCHEMBL7254814 | 0.71 | SMN1; SMN2 (0.38) | PSIP1JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6503935-B1 | Treating urinary incontinence or retrograde ejaculation | ABBOTT LABORATORIES | 2003-01-07 | — | — | US | disclosed |
| EP-1102754-A1 | IMIDAZOLES AND RELATED COMPOUNDS AS ALPHA-1A AGONISTS | ABBOTT LABORATORIES (US) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000007997-A1 | IMIDAZOLES AND RELATED COMPOUNDS AS α1A AGONISTS | ABBOTT LABORATORIES (US) | 2000-02-17 | — | — | WO | disclosed |