SCHEMBL725480

SCHEMBL725480

CC(C)c1cncc(C(C)C)c1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRMT5 O14744 1/20 0.34
WDR77 Q9BQA1 1/20 0.34
LMNA P02545 3/20 0.33
GABRA1 P14867 1/20 0.32
GABRB2 P47870 1/20 0.32
TRPA1 O75762 1/20 0.32
PTGS1 P23219 1/20 0.32
CACNA1C Q13936 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.31
NOTUM Q6P988 1/20 0.31
GAA P10253 2/20 0.31
FABP3 P05413 2/20 0.31
FABP4 P15090 2/20 0.31
ALDH1A1 P00352 1/20 0.31
ALOX12 P18054 1/20 0.31
HTT P42858 1/20 0.31
HIF1A Q16665 1/20 0.31
MEN1 O00255 1/20 0.31
HPGD P15428 1/20 0.31
KMT2A Q03164 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28361799 0.97 PRMT5 (0.33) PRMT5WDR77LMNAGABRA1GABRB2
SCHEMBL21100843 0.87 PRMT5 (0.31) PRMT5WDR77
SCHEMBL19635576 0.87 PRMT5 (0.31) PRMT5WDR77
SCHEMBL20691202 0.87 PRMT5 (0.33) PRMT5WDR77CYP11B1CYP11B2
SCHEMBL3509806 0.87 ADRB2 (0.34) PRMT5WDR77GABRA1GABRB2GAA
SCHEMBL8065482 0.87 ADRB2 (0.34) PRMT5WDR77GABRA1GABRB2GAA
SCHEMBL12758856 0.87 CYP11B1 (0.38) PRMT5WDR77LMNAGAAMEN1
SCHEMBL24362607 0.85 PRMT5 (0.33) PRMT5WDR77
SCHEMBL798755 0.84 HCAR2 (0.40) PRMT5WDR77LMNATRPA1PTGS1
SCHEMBL23260180 0.83 ALDH1A1 (0.36) PRMT5WDR77LMNASMN1; SMN2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 760 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116284510-A Metallocene catalyst, preparation method and application thereof 万华化学集团股份有限公司 2023-06-23 CN claimed
CN-115947646-A Method for photo-catalytic hydroxylation of aryl or heteroaryl halide 浙江工业大学 2023-04-11 CN claimed
WO-2026090602-A1 PIGMENTED RESIN AND CATALYST COMPOSITIONS MATERIA, INC. (US) 2026-04-30 WO disclosed
EP-3110862-B1 ADHESION PROMOTER COMPOSITIONS FOR CYCLIC OLEFIN RESIN COMPOSITIONS ExxonMobil Product Solutions Company (US) 2026-04-01 EP disclosed
EP-4683900-A2 ROMP AND THERMAL INSULATION COMPOSITIONS AND MATERIALS AND USE THEREOF Materia, Inc. (US) 2026-01-28 EP disclosed
WO-2025245037-A1 CYCLIC OLEFIN COMPOSITIONS, ROMP COMPOSITIONS THEREOF, AND APPLICATIONS THEREOF MATERIA, INC. (US) 2025-11-27 WO disclosed
EP-4194092-B1 SYNTHESIS AND CHARACTERIZATION OF METATHESIS CATALYSTS UMICORE AG & CO KG (DE) 2025-10-22 EP disclosed
EP-2970522-B1 IN-MOLD COATING OF ROMP POLYMERS MATERIA INC (US) 2025-05-21 EP disclosed
EP-3013886-B1 THERMAL INSULATION MATERIA INC (US) 2025-03-26 EP disclosed
EP-2961778-B1 METAL CARBENE OLEFIN METATHESIS TWO CATALYST COMPOSITION MATERIA INC (US) 2025-02-26 EP disclosed
US-20250026871-A1 CYCLIC RUTHENIUM BENZYLIDENE INITIATORS FOR ENHANCED RING EXPANSION METATHESIS POLYMERIZATION UNIVERSITY OF WASHINGTON (US) 2025-01-23 US disclosed
US-20030236427-A1 Cross-metathesis of olefins directly substituted with an electron-withdrawing group using transition metal carbene catalysts NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2003-12-25 US disclosed
WO-2003087167-A2 CROSS-METATHESIS OF OLEFINS DIRECTLY SUBSTITUTED WITH AN ELECTRON-WITHDRAWING GROUP USING TRANSITION METAL CARBENE CATALYSTS CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2003-10-23 WO disclosed
US-5438143-A Process for the preparation of substituted pyridines via 1-aza-1,3-butadienes and the 1-aza-1,3-butadiene intermediates DSM N.V. (NL) 1995-08-01 US disclosed
EP-0543880-B1 PROCESS FOR THE PREPARATION OF SUBSTITUTED PYRIDINES VIA 1-AZA-1,3-BUTADIENES AND THE 1-AZA-1,3-BUTADIENE INTERMEDIATES DSM NV (NL) 1995-04-19 EP disclosed
EP-0543880-A1 PROCESS FOR THE PREPARATION OF SUBSTITUTED PYRIDINES VIA 1-AZA-1,3-BUTADIENES AND THE 1-AZA-1,3-BUTADIENE INTERMEDIATES. DSM NV (NL) 1993-06-02 EP disclosed
WO-1992002505-A1 PROCESS FOR THE PREPARATION OF SUBSTITUTED PYRIDINES VIA 1-AZA-1,3-BUTADIENES AND THE 1-AZA-1,3-BUTADIENE INTERMEDIATES DSM N.V. (NL) 1992-02-20 WO disclosed
EP-0070012-B1 PROCESS FOR PREPARING 3,5-DIALKYL PYRIDINES LONZA AG (CH) 1987-10-21 EP disclosed
US-4429131-A Process for the production of 3,5-dialkylpyridines LONZA LTD. (CH) 1984-01-31 US disclosed
EP-0070012-A2 Process for preparing 3,5-dialkyl pyridines LONZA AG (CH) 1983-01-19 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030236427-A1 Cross-metathesis of olefins directly substituted with an electron-withdrawing group using transition metal carbene catalysts OXER1, DUOX2, AOC2 PRMT5 1812/4885WDR77 3838/4885LMNA 4692/4885
US-20250026871-A1 CYCLIC RUTHENIUM BENZYLIDENE INITIATORS FOR ENHANCED RING EXPANSION METATHESIS POLYMERIZATION MCM7, MCM4, MCM5 PRMT5 196/4885WDR77 3711/4885LMNA 4642/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.