Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 3/20 | 0.48 |
| ▸ | MAOB | P27338 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.44 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.41 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.41 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.41 |
| ▸ | EIF4E | P06730 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1753088 | 0.83 | CASP1 (0.53) | CASP1MAOBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL7256443 | 0.82 | TDP1 (0.40) | SMN1; SMN2PKMEIF4EXDHGRM5 | |
| SCHEMBL1752831 | 0.77 | SMARCA2 (0.59) | CASP1MAOBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL24500388 | 0.75 | MEN1 (0.62) | MAOBSMN1; SMN2MAPTAGTR1EIF4E | |
| SCHEMBL29506697 | 0.72 | LMNA (0.52) | SMN1; SMN2NPC1RAB9AXDHMEN1 | |
| Benzene SCHEMBL28725386 | 0.72 | LMNA (0.52) | SMN1; SMN2NPC1RAB9AXDHMEN1 | |
| SCHEMBL184258 | 0.72 | LMNA (0.52) | SMN1; SMN2NPC1RAB9AXDHMEN1 | |
| SCHEMBL96494 | 0.71 | LMNA (0.57) | SMN1; SMN2NPC1RAB9AXDHMEN1 | |
| Benzene SCHEMBL27923728 | 0.71 | LMNA (0.57) | SMN1; SMN2NPC1RAB9AXDHMEN1 | |
| SCHEMBL24500394 | 0.71 | MEN1 (0.50) | MAOBSMN1; SMN2MAPTXDHMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003080616-A1 | PYRAZOLOPYRIDAZINE DERIVATIVES, PROCESS FOR PREPARATION AND USE FOR THE INHIBITION OF GSK-3 | GLAXO GROUP LIMITED (GB) | 2003-10-02 | — | — | WO | disclosed |