Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7255658 | 0.82 | CASP1 (0.48) | TDP1MEN1LMNATHRBBLM | |
| SCHEMBL249552 | 0.74 | KMT2A (0.71) | TDP1MEN1LMNATHRBBLM | |
| SCHEMBL31175932 | 0.74 | KMT2A (0.71) | TDP1MEN1LMNATHRBBLM | |
| SCHEMBL1915276 | 0.74 | LMNA (0.41) | TDP1MEN1LMNATHRBBLM | |
| SCHEMBL7756808 | 0.73 | TDP1 (0.44) | TDP1MEN1LMNATHRBBLM | |
| SCHEMBL23948729 | 0.73 | TRIM24 (0.50) | TDP1MEN1LMNATHRBBLM | |
| SCHEMBL30994217 | 0.73 | PBRM1 (0.42) | TDP1LMNAKMT2APLK4AURKA | |
| SCHEMBL27511393 | 0.72 | KMT2A (0.67) | TDP1MEN1LMNATHRBBLM | |
| SCHEMBL31588841 | 0.72 | KMT2A (0.67) | TDP1MEN1LMNATHRBBLM | |
| SCHEMBL21464347 | 0.71 | XDH (0.44) | TDP1MEN1LMNATHRBBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003080616-A1 | PYRAZOLOPYRIDAZINE DERIVATIVES, PROCESS FOR PREPARATION AND USE FOR THE INHIBITION OF GSK-3 | GLAXO GROUP LIMITED (GB) | 2003-10-02 | — | — | WO | disclosed |