Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.54 |
| ▸ | ALPL | P05186 | 2/20 | 0.54 |
| ▸ | RPA1 | P27694 | 1/20 | 0.54 |
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7259134 | 0.80 | ALPL (0.54) | ALPLMAPTMEN1NPC1KMT2A | |
| SCHEMBL27604947 | 0.79 | MAPT (0.54) | MAPK1MAPTTP53MEN1NPC1 | |
| SCHEMBL7255684 | 0.79 | POLB (0.61) | CA12ALPLMAPK1MAPTTP53 | |
| SCHEMBL9049682 | 0.78 | MAPT (0.66) | MAPK1MAPTTP53MEN1NPC1 | |
| SCHEMBL9047596 | 0.78 | MAPT (0.66) | MAPK1MAPTTP53MEN1NPC1 | |
| SCHEMBL14985510 | 0.78 | RAB9A (0.64) | CA12ALPLRPA1MAPK1MAPT | |
| SCHEMBL14844836 | 0.76 | CA12 (0.54) | CA12ALPLRPA1CRHBPMAPK1 | |
| SCHEMBL2360295 | 0.76 | NPC1 (0.67) | CA12ALPLRPA1CRHBPMAPK1 | |
| SCHEMBL1608472 | 0.76 | RAB9A (0.62) | CA12ALPLRPA1MAPK1MAPT | |
| SCHEMBL22593931 | 0.76 | CA12 (0.54) | CA12ALPLRPA1CRHBPMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003080616-A1 | PYRAZOLOPYRIDAZINE DERIVATIVES, PROCESS FOR PREPARATION AND USE FOR THE INHIBITION OF GSK-3 | GLAXO GROUP LIMITED (GB) | 2003-10-02 | — | — | WO | disclosed |