Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 10/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NQO1 | P15559 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8019789 | 0.98 | ACHE (0.42) | ACHENQO1CA12CA1CA2 | |
| SCHEMBL10999954 | 0.79 | MAPT (0.53) | ACHEMEN1POLBKMT2ANQO1 | |
| Iodide SCHEMBL2333206 | 0.76 | SIRT1 (0.39) | ACHE | |
| SCHEMBL20180489 | 0.75 | ACHE (0.48) | ACHEMEN1POLBKMT2ALMNA | |
| Iodide SCHEMBL336306 | 0.74 | PRKCA (0.58) | ACHEMEN1POLBKMT2ALMNA | |
| Iodide SCHEMBL10549487 | 0.74 | ACHE (0.44) | ACHEMEN1POLBKMT2ALMNA | |
| Iodide SCHEMBL29918121 | 0.74 | PRKCA (0.58) | ACHEMEN1POLBKMT2ALMNA | |
| SCHEMBL337016 | 0.72 | PRKCA (0.57) | ACHEMEN1POLBKMT2ALMNA | |
| SCHEMBL7256323 | 0.72 | ACHE (0.45) | ACHEMEN1POLBKMT2ALMNA | |
| SCHEMBL11797426 | 0.71 | KMT2A (0.49) | ACHEMEN1KMT2ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6635090-B1 | Dyeing method using a specific cationic derivative and a compound selected among a specific aldehyde, a specific ketone, a quinone and a di-imino-isoindoline or 3-amino-isoindolone derivative | L'OREAL, S.A. (FR) | 2003-10-21 | — | — | US | claimed |
| US-6635090-B1 | Dyeing method using a specific cationic derivative and a compound selected among a specific aldehyde, a specific ketone, a quinone and a di-imino-isoindoline or 3-amino-isoindolone derivative | L'OREAL, S.A. (FR) | 2003-10-21 | — | — | US | disclosed |
| EP-0740689-B1 | SUBSTITUTED UNSYMMETRICAL CYANINE DYES WITH SELECTED PERMEABILITY | MOLECULAR PROBES INC (US) | 2002-01-30 | — | — | EP | disclosed |
| US-5658751-A | SUBSTITUENTS ON PYRIDINIUM OR QUINOLINIUM RING SYSTEM SERVE TO INCREASE OR DECREASE PERMEABILITY, SELECTIVITY AND BINDING AFFINITY OF NUCLEIC ACID STAINS; FORM FLUORESCENT COMPLEXES WITH NUCLEIC ACIDS | MOLECULAR PROBES, INC. (US) | 1997-08-19 | — | — | US | disclosed |
| EP-0740689-A1 | SUBSTITUTED UNSYMMETRICAL CYANINE DYES WITH SELECTED PERMEABILITY | MOLECULAR PROBES INC (US) | 1996-11-06 | — | — | EP | disclosed |
| WO-1996013552-A2 | SUBSTITUTED UNSYMMETRICAL CYANINE DYES WITH SELECTED PERMEABILITY | MOLECULAR PROBES, INC. (US) | 1996-05-09 | — | — | WO | disclosed |