Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 13/20 | 0.47 |
| ▸ | PTGDR | Q13258 | 6/20 | 0.47 |
| ▸ | THRB | P10828 | 3/20 | 0.44 |
| ▸ | THRA | P10827 | 2/20 | 0.44 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7346441 | 0.91 | PTGDR2 (0.43) | PTGDR2PTGDRPTGER2POLBL3MBTL1 | |
| SCHEMBL7256754 | 0.85 | THRB (0.51) | PTGDR2PTGDRTHRBTHRAPTGER2 | |
| SCHEMBL7260747 | 0.84 | THRB (0.49) | PTGDR2PTGDRTHRBTHRAPOLB | |
| SCHEMBL7256723 | 0.79 | CA5A (0.44) | PTGDR2THRBTHRACA5APOLB | |
| SCHEMBL7792682 | 0.79 | PTGDR2 (0.57) | PTGDR2PTGDRPTGER2CA5AALDH1A1 | |
| SCHEMBL7347408 | 0.78 | THRB (0.39) | PTGDR2PTGDRTHRBTHRAPOLB | |
| SCHEMBL7350727 | 0.78 | NR3C1 (0.46) | THRBTHRACA5APOLBL3MBTL1 | |
| SCHEMBL8574560 | 0.77 | GAA (0.57) | PTGDR2PTGDRPTGER2CA5AALDH1A1 | |
| SCHEMBL7256740 | 0.75 | MMP2 (0.44) | THRBTHRAALDH1A1TSHR | |
| SCHEMBL23691560 | 0.73 | POLB (0.39) | POLBALDH1A1GAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6646005-B1 | Administering nontoxic sulfur compounds such as 3,5-dibromo-4-(4-hydroxy-3-iodophenylsulfonyl)phenylacetic acid, having side effect reduction; alopecia | THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER | 2003-11-11 | — | — | US | claimed |
| EP-1185232-A1 | METHOD OF TREATING HAIR LOSS USING SULFONYL THYROMIMETIC COMPOUNDS | UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER (US) | 2002-03-13 | — | — | EP | claimed |
| WO-2000072810-A1 | METHOD OF TREATING HAIR LOSS USING SULFONYL THYROMIMETIC COMPOUNDS | THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER (US) | 2000-12-07 | — | — | WO | claimed |
| US-5284971-A | No cardiac side effects | SYNTEX (U.S.A.) INC. (US) | 1994-02-08 | — | — | US | claimed |
| US-6646005-B1 | Administering nontoxic sulfur compounds such as 3,5-dibromo-4-(4-hydroxy-3-iodophenylsulfonyl)phenylacetic acid, having side effect reduction; alopecia | THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER | 2003-11-11 | — | — | US | disclosed |
| EP-1185232-A1 | METHOD OF TREATING HAIR LOSS USING SULFONYL THYROMIMETIC COMPOUNDS | UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER (US) | 2002-03-13 | — | — | EP | disclosed |
| WO-2000072810-A1 | METHOD OF TREATING HAIR LOSS USING SULFONYL THYROMIMETIC COMPOUNDS | THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER (US) | 2000-12-07 | — | — | WO | disclosed |
| US-5284971-A | No cardiac side effects | SYNTEX (U.S.A.) INC. (US) | 1994-02-08 | — | — | US | disclosed |