Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | AXL | P30530 | 3/20 | 0.45 |
| ▸ | MERTK | Q12866 | 2/20 | 0.45 |
| ▸ | PYGL | P06737 | 5/20 | 0.44 |
| ▸ | PYGM | P11217 | 5/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | GCK | P35557 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7263206 | 0.82 | PDGFRA (0.47) | POLBAXLALDH1A1PDGFRAPDGFRB | |
| SCHEMBL7262915 | 0.80 | AKR1C3 (0.51) | METALDH1A1RAB9AHPGDMAPT | |
| SCHEMBL7263203 | 0.79 | PDGFRA (0.50) | AXLALDH1A1PDGFRAPDGFRBMAPT | |
| SCHEMBL7258432 | 0.78 | TUBB1 (0.46) | KDM4EPOLBAXLALDH1A1RAB9A | |
| SCHEMBL7263674 | 0.76 | THRB (0.44) | RAB9APDGFRAPDGFRBHTTFGFR2 | |
| SCHEMBL27151239 | 0.76 | KDM4E (0.57) | KDM4EPOLBALDH1A1RAB9ALMNA | |
| SCHEMBL7258379 | 0.76 | FGFR2 (0.44) | KDM4EALDH1A1PDGFRAPDGFRBHTT | |
| SCHEMBL6693009 | 0.74 | KDM4E (0.49) | KDM4EPOLBPYGLPYGMALDH1A1 | |
| SCHEMBL503802 | 0.74 | POLB (0.70) | KDM4EPOLBALDH1A1RAB9ALMNA | |
| SCHEMBL8572013 | 0.73 | KDM4E (0.69) | KDM4EPOLBALDH1A1HPGDHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003094845-A2 | PYRIDINE-BASED THYROID RECEPTOR LIGANDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-11-20 | — | — | WO | disclosed |