Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 4/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7258836 | 0.82 | KDM4E (0.52) | PDGFRAPDGFRBKDRALDH1A1FGFR2 | |
| SCHEMBL7263203 | 0.82 | PDGFRA (0.50) | PDGFRAPDGFRBEGFRKDRALDH1A1 | |
| SCHEMBL7263674 | 0.82 | THRB (0.44) | PDGFRAPDGFRBCYP2D6FGFR2 | |
| SCHEMBL7258379 | 0.81 | FGFR2 (0.44) | PDGFRAPDGFRBKDRTRPA1CYP1A2 | |
| SCHEMBL7258432 | 0.81 | TUBB1 (0.46) | PDGFRAPDGFRBKDRCYP1A2CYP2C9 | |
| SCHEMBL7262694 | 0.72 | LMNA (0.58) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL6692393 | 0.71 | THRB (0.39) | EGFRKDRALDH1A1POLB | |
| SCHEMBL30851753 | 0.70 | HPGD (0.40) | PDGFRAPDGFRBEGFRTRPA1CYP1A2 | |
| SCHEMBL29634588 | 0.69 | CA12 (0.65) | CYP1A2CYP3A4CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL258418 | 0.69 | CA12 (0.65) | CYP1A2CYP3A4CYP2D6CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003094845-A2 | PYRIDINE-BASED THYROID RECEPTOR LIGANDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-11-20 | — | — | WO | disclosed |