Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7263206 | 0.81 | PDGFRA (0.47) | FGFR2ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7263203 | 0.81 | PDGFRA (0.50) | FGFR2ALDH1A1PDGFRAKDRPDGFRB | |
| SCHEMBL7263674 | 0.78 | THRB (0.44) | FGFR2MEN1KMT2ACYP2D6PDGFRA | |
| SCHEMBL7258432 | 0.77 | TUBB1 (0.46) | FGFR2ALDH1A1CYP1A2KDM4EPDGFRA | |
| SCHEMBL7258836 | 0.76 | KDM4E (0.52) | FGFR2ALDH1A1KDM4ENPSR1PDGFRA | |
| SCHEMBL7486400 | 0.68 | FGFR2 (0.84) | FGFR2PDGFRAKDRPDGFRB | |
| SCHEMBL4074317 | 0.67 | ALDH1A1 (0.36) | ALDH1A1CYP1A2CYP3A4CYP2D6RXFP1 | |
| SCHEMBL4375741 | 0.67 | GAK (0.38) | CYP1A2CYP3A4CYP2D6TRPA1CYP2C9 | |
| SCHEMBL11580995 | 0.66 | CA1 (0.79) | MEN1KMT2AALDH1A1CYP3A4KDM4E | |
| SCHEMBL83811 | 0.66 | CA1 (0.79) | MEN1KMT2AALDH1A1CYP3A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003094845-A2 | PYRIDINE-BASED THYROID RECEPTOR LIGANDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-11-20 | — | — | WO | disclosed |