Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 5/20 | 0.42 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CTSA | P10619 | 1/20 | 0.37 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7263079 | 0.90 | TP53 (0.46) | ROCK2ROCK1TP53SMN1; SMN2NPC1 | |
| SCHEMBL7259217 | 0.89 | SMN1; SMN2 (0.41) | ROCK2ROCK1TP53SMN1; SMN2NPC1 | |
| SCHEMBL7258783 | 0.89 | ROCK2 (0.37) | FAAHROCK2ROCK1TP53SMN1; SMN2 | |
| SCHEMBL7259234 | 0.87 | FFAR4 (0.41) | ROCK2ROCK1TP53SMN1; SMN2NPC1 | |
| SCHEMBL7259490 | 0.87 | CNR1 (0.39) | ROCK2ROCK1TP53SMN1; SMN2NPC1 | |
| SCHEMBL7259376 | 0.86 | MRGPRX4 (0.39) | ROCK2ROCK1TP53SMN1; SMN2NPC1 | |
| SCHEMBL7263737 | 0.85 | AVPR1B (0.41) | TP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL7258741 | 0.81 | HSD17B1 (0.38) | HSD17B1HSD17B2ROCK1TP53SMN1; SMN2 | |
| SCHEMBL7258877 | 0.81 | SMN1; SMN2 (0.40) | ROCK2ROCK1TP53SMN1; SMN2NPC1 | |
| SCHEMBL7263757 | 0.81 | HDAC1 (0.40) | CTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003006437-A1 | IMIDAZOLE DERIVATIVES AS ADENOSINE DEAMINASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-01-23 | — | — | WO | claimed |
| WO-2003006437-A1 | IMIDAZOLE DERIVATIVES AS ADENOSINE DEAMINASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-01-23 | — | — | WO | disclosed |