Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 2/20 | 0.41 |
| ▸ | PLD1 | Q13393 | 2/20 | 0.41 |
| ▸ | NCF1 | P14598 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.35 |
| ▸ | HTR3B | O95264 | 4/20 | 0.35 |
| ▸ | HTR3A | P46098 | 4/20 | 0.35 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.35 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4421143 | 0.83 | ADRB2 (0.40) | ADRB2PLD1NCF1ALDH1A1KDM4E | |
| SCHEMBL13611642 | 0.69 | ADRB2 (0.46) | ADRB2PLD1NCF1ALDH1A1KDM4E | |
| SCHEMBL27511861 | 0.63 | ADRB2 (0.36) | ADRB2PLD1NCF1ALDH1A1KDM4E | |
| SCHEMBL3712448 | 0.63 | CHRNB2 (0.33) | CHRNB2CHRNA4 | |
| SCHEMBL4418589 | 0.63 | ADRB2 (0.35) | ADRB2PLD1NCF1ALDH1A1KDM4E | |
| SCHEMBL74335 | 0.58 | ADRB2 (1.00) | ADRB2PLD1NCF1ALDH1A1KDM4E | |
| SCHEMBL894239 | 0.58 | ADRB2 (1.00) | ADRB2PLD1NCF1ALDH1A1KDM4E | |
| SCHEMBL7668734 | 0.58 | PLD1 (0.47) | ADRB2PLD1NCF1ALDH1A1KDM4E | |
| SCHEMBL11892889 | 0.58 | HRH1 (0.39) | ADRB2PLD1NCF1ALDH1A1KDM4E | |
| SCHEMBL726035 | 0.58 | ADRB2 (0.37) | ADRB2PLD1NCF1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4694834-B2 | — | — | 2011-06-08 | — | — | JP | claimed |
| EP-1539700-A4 | 8-HYDROXY QUINOLINE DERIVATIVES | PRANA BIOTECHNOLOGY LTD (AU) | 2006-06-28 | — | — | EP | claimed |
| JP-2006504646-A | — | — | 2006-02-09 | — | — | JP | claimed |
| EP-1539700-A1 | 8-HYDROXY QUINOLINE DERIVATIVES | Prana Biotechnology Ltd (AU) | 2005-06-15 | — | — | EP | claimed |
| WO-2004007461-A1 | 8-HYDROXY QUINOLINE DERIVATIVES | PRANA BIOTECHNOLOGY LIMITED (AU) | 2004-01-22 | — | — | WO | claimed |
| EP-2012789-A1 | METHOD OF TREATMENT OF AGE-RELATED MACULAR DEGENERATION(AMD) | Prana Biotechnology Limited (AU) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007118276-A1 | METHOD OF TREATMENT OF AGE-RELATED MACULAR DEGENERATION(AMD) | PRANA BIOTECHNOLOGY LTD (AU) | 2007-10-25 | — | — | WO | disclosed |
| EP-1539700-A4 | 8-HYDROXY QUINOLINE DERIVATIVES | PRANA BIOTECHNOLOGY LTD (AU) | 2006-06-28 | — | — | EP | disclosed |
| US-20060089380-A1 | 8-Hydroxy quinoline derivatives | PRANA BIOTECHNOLOGY LTD. (AU) | 2006-04-27 | — | — | US | disclosed |
| EP-1539700-A1 | 8-HYDROXY QUINOLINE DERIVATIVES | Prana Biotechnology Ltd (AU) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004007461-A1 | 8-HYDROXY QUINOLINE DERIVATIVES | PRANA BIOTECHNOLOGY LIMITED (AU) | 2004-01-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060089380-A1 | 8-Hydroxy quinoline derivatives | PARK7, HTT, SNCA | ADRB2 1454/4885PLD1 4405/4885NCF1 1995/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.