Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | NAMPT | P43490 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7261085 | 0.90 | MMP13 (0.49) | ALDH1A1NAMPTSMN1; SMN2HTTLMNA | |
| SCHEMBL7266750 | 0.86 | NAMPT (0.44) | NAMPTLMNAPARP1 | |
| SCHEMBL7265019 | 0.83 | LMNA (0.52) | ALDH1A1NAMPTHTTKDM4EPOLB | |
| SCHEMBL7266274 | 0.81 | HPGD (0.48) | ALDH1A1SMN1; SMN2KDM4EPOLBTDP1 | |
| SCHEMBL7260372 | 0.81 | MAPK14 (0.45) | PARP1 | |
| SCHEMBL7266685 | 0.80 | NPSR1 (0.49) | ALDH1A1KDM4EKMT2AJAK1 | |
| SCHEMBL7260419 | 0.77 | HTT (0.42) | HTTPARP1 | |
| SCHEMBL7265103 | 0.76 | NPC1 (0.46) | ALDH1A1SMN1; SMN2GAAKMT2APARP1 | |
| SCHEMBL7261107 | 0.76 | ROCK2 (0.48) | PARP1 | |
| SCHEMBL6199833 | 0.72 | PARP1 (0.66) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003103666-A2 | NOVEL 4,5-DIHYDRO-IMIDAZO[4,5,1-IJ]QUINOLIN-6-ONES | ALTANA PHARMA AG (DE) | 2003-12-18 | — | — | WO | claimed |
| WO-2003103666-A2 | NOVEL 4,5-DIHYDRO-IMIDAZO[4,5,1-IJ]QUINOLIN-6-ONES | ALTANA PHARMA AG (DE) | 2003-12-18 | — | — | WO | disclosed |