Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 14/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7261107 | 0.84 | ROCK2 (0.48) | PARP1 | |
| SCHEMBL7266288 | 0.83 | NPC1 (0.47) | PARP1TP53 | |
| SCHEMBL7260415 | 0.82 | ROCK1 (0.43) | PARP1 | |
| SCHEMBL7265103 | 0.79 | NPC1 (0.46) | PARP1TP53HTR3A | |
| SCHEMBL7260381 | 0.79 | NPC1 (0.46) | PARP1TP53HTR3A | |
| SCHEMBL7260372 | 0.78 | MAPK14 (0.45) | PARP1KCNH2GRM2 | |
| SCHEMBL7266685 | 0.77 | NPSR1 (0.49) | — | |
| SCHEMBL7261085 | 0.76 | MMP13 (0.49) | PARP1 | |
| SCHEMBL6199833 | 0.75 | PARP1 (0.66) | PARP1HTR3AKCNH2GRM2 | |
| SCHEMBL7266274 | 0.75 | HPGD (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003103666-A2 | NOVEL 4,5-DIHYDRO-IMIDAZO[4,5,1-IJ]QUINOLIN-6-ONES | ALTANA PHARMA AG (DE) | 2003-12-18 | — | — | WO | claimed |
| WO-2003103666-A2 | NOVEL 4,5-DIHYDRO-IMIDAZO[4,5,1-IJ]QUINOLIN-6-ONES | ALTANA PHARMA AG (DE) | 2003-12-18 | — | — | WO | disclosed |