Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7261120 | 0.83 | ALDH1A1 (0.48) | LMNAPOLBKDM4EALDH1A1NAMPT | |
| SCHEMBL7266274 | 0.82 | HPGD (0.48) | LMNAPOLBKDM4EALDH1A1PKM | |
| SCHEMBL7266288 | 0.81 | NPC1 (0.47) | LMNANPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL7266750 | 0.81 | NAMPT (0.44) | LMNANAMPTPARP1 | |
| SCHEMBL7261724 | 0.78 | CD274 (0.56) | NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL7260381 | 0.77 | NPC1 (0.46) | NPC1RAB9AALDH1A1KMT2APARP1 | |
| SCHEMBL7265103 | 0.77 | NPC1 (0.46) | NPC1RAB9AALDH1A1KMT2APARP1 | |
| SCHEMBL6199833 | 0.75 | PARP1 (0.66) | PARP1 | |
| SCHEMBL7261107 | 0.74 | ROCK2 (0.48) | PARP1 | |
| SCHEMBL7266692 | 0.73 | HTR2B (0.45) | NAMPTPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003103666-A2 | NOVEL 4,5-DIHYDRO-IMIDAZO[4,5,1-IJ]QUINOLIN-6-ONES | ALTANA PHARMA AG (DE) | 2003-12-18 | — | — | WO | claimed |
| WO-2003103666-A2 | NOVEL 4,5-DIHYDRO-IMIDAZO[4,5,1-IJ]QUINOLIN-6-ONES | ALTANA PHARMA AG (DE) | 2003-12-18 | — | — | WO | disclosed |