SCHEMBL726189

SCHEMBL726189

C=CC(=O)c1cccc2ccccc12

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR4A1 P22736 1/20 0.59
NR4A2 P43354 1/20 0.59
NR4A3 Q92570 1/20 0.59
MMP3 P08254 1/20 0.53
HDAC8 Q9BY41 1/20 0.53
CDC25B P30305 2/20 0.52
PTPN1 P18031 1/20 0.52
PLK1 P53350 1/20 0.52
GPR52 Q9Y2T5 1/20 0.51
PTK2B Q14289 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
KMT2A Q03164 3/20 0.49
ALDH1A1 P00352 3/20 0.49
KDM4E B2RXH2 2/20 0.49
MEN1 O00255 2/20 0.49
TP53 P04637 2/20 0.49
MAPT P10636 2/20 0.49
HPGD P15428 2/20 0.49
MAPK1 P28482 2/20 0.49
CYP3A4 P08684 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29465774 1.00 NR4A1 (0.59) NR4A1NR4A2NR4A3MMP3HDAC8
SCHEMBL11527779 0.83 NR4A1 (0.63) NR4A1NR4A2NR4A3MMP3HDAC8
SCHEMBL3553966 0.83 KDM4E (0.61) NR4A1NR4A2NR4A3MMP3HDAC8
SCHEMBL29884133 0.82 NR4A1 (0.61) NR4A1NR4A2NR4A3MMP3HDAC8
SCHEMBL1192932 0.82 NR4A1 (0.61) NR4A1NR4A2NR4A3MMP3HDAC8
SCHEMBL10347642 0.80 AKT1 (0.61) KMT2AALDH1A1KDM4EMEN1TP53
SCHEMBL2538243 0.80 NR4A1 (0.59) NR4A1NR4A2NR4A3MMP3HDAC8
SCHEMBL28905662 0.80 NR4A1 (0.59) NR4A1NR4A2NR4A3MMP3HDAC8
Water SCHEMBL28515047 0.80 NR4A1 (0.59) NR4A1NR4A2NR4A3MMP3HDAC8
SCHEMBL15619815 0.79 LDHA (0.62) CYP1A1CYP1A2CYP1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 79 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115650837-B Method for preparing ketone compound by 1,4 addition reaction of alpha, beta unsaturated ketene 南京工业大学 2024-05-17 CN claimed
CN-115650837-A Method for preparing ketone compound by utilizing 1,4 addition reaction of alpha, beta unsaturated ketene 南京工业大学 2023-01-31 CN claimed
EP-1963387-B1 TIRE HAVING A COLORED SURFACE PIRELLI (IT) 2014-06-04 EP claimed
US-8196627-B2 Tire having a coated surface PIRELLI TYRE S.P.A. (IT) 2012-06-12 US claimed
US-8151848-B2 Tire having a colored surface PIRELLI TYRE S.P.A. (IT) 2012-04-10 US claimed
JP-4828610-B2 2011-11-30 JP claimed
JP-4772147-B2 2011-09-14 JP claimed
US-20100024942-A1 Tire Having a Colored Surface PIRELLI TYRE S.P.A. (IT) 2010-02-04 US claimed
EP-2021420-B1 TIRE HAVING A COATED SURFACE PIRELLI (IT) 2009-10-21 EP claimed
US-20090250150-A1 Tire having a coated surface PIRELLI TYRE S.P.A. (IT) 2009-10-08 US claimed
JP-2009520616-A 2009-05-28 JP claimed
EP-2021420-A1 TIRE HAVING A COATED SURFACE Pirelli Tyre S.p.A. (IT) 2009-02-11 EP claimed
EP-1963387-A1 TIRE HAVING A COLORED SURFACE PIRELLI TYRE S.p.A. (IT) 2008-09-03 EP claimed
WO-2007137608-A1 TIRE HAVING A COATED SURFACE PIRELLI TYRE S.P.A. (IT) 2007-12-06 WO claimed
WO-2007071272-A1 TIRE HAVING A COLORED SURFACE PIRELLI TYRE S.P.A. (IT) 2007-06-28 WO claimed
EP-0015750-B1 1-(NAPHTHYL-N-PROPYL)IMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, METHODS OF MAKING THEM AND THEIR USE FOR PHARMACEUTICALS SYNTEX (U.S.A.) INC. (US) 1982-11-24 EP claimed
EP-0015750-A1 1-(Naphthyl-n-propyl)imidazole derivatives, compositions containing them, methods of making them and their use for pharmaceuticals SYNTEX (U.S.A.) INC. (US) 1980-09-17 EP claimed
US-4095017-A VINYL MONOMER POLYMERIZATION OR COPOLYMERIZATION CATALYZED BY ORGANOALUMINUM-ORGANOPHOSPHINE-METAL SALT OF A BETA-DIKETONE CATALYST SYSTEM PHILLIPS PETROLEUM COMPANY (US) 1978-06-13 US claimed
US-3997708-A ADDITION PHILLIPS PETROLEUM COMPANY (US) 1976-12-14 US claimed
CN-115650837-B Method for preparing ketone compound by 1,4 addition reaction of alpha, beta unsaturated ketene 南京工业大学 2024-05-17 CN disclosed
CN-117777057-A Synthesis method of chiral gamma-amino alcohol 湖州学院 2024-03-29 CN disclosed
CN-115650837-A Method for preparing ketone compound by utilizing 1,4 addition reaction of alpha, beta unsaturated ketene 南京工业大学 2023-01-31 CN disclosed
CN-115551496-A STAT inhibitory compounds and compositions 詹皮克斯有限公司 2022-12-30 CN disclosed
CN-115551490-A Alpha-substituted STAT inhibitors and compositions thereof 詹皮克斯有限公司 2022-12-30 CN disclosed
CN-115443129-A KCNT1 inhibitors and methods of use 普拉西斯精密医药公司 2022-12-06 CN disclosed
CN-115403495-A Method for synthesizing chiral 1, 3-mercaptan 陕西师范大学 2022-11-29 CN disclosed
CN-115215923-A Macrocyclic broad spectrum antibiotics 豪夫迈·罗氏有限公司 2022-10-21 CN disclosed
CN-114007605-B Macrocyclic broad spectrum antibiotics 豪夫迈·罗氏有限公司 2022-07-15 CN disclosed
CN-114269340-A KCNT1 inhibitors and methods of use 普拉克西斯精密药物股份有限公司 2022-04-01 CN disclosed
CN-114007605-A Macrocyclic broad spectrum antibiotics 豪夫迈·罗氏有限公司 2022-02-01 CN disclosed
CN-111560039-A Ancillary ligands for organometallic complexes and devices and formulations including the same 环球展览公司 2020-08-21 CN disclosed
CN-104277075-B Ancillary ligands for organometallic complexes and devices and formulations including the same 环球展览公司 2020-05-22 CN disclosed
CN-105884647-A Synthesis method of 3-hydroxyl diazoester intermediate alkyne compound 湖北科技学院 2016-08-24 CN disclosed
US-8937091-B2 Inhibitor of protein crosslinking and use of the same JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) 2015-01-20 US disclosed
US-8937091-B2 Inhibitor of protein crosslinking and use of the same JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) 2015-01-20 US disclosed
US-8937091-B2 Inhibitor of protein crosslinking and use of the same JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) 2015-01-20 US disclosed
EP-1963387-B1 TIRE HAVING A COLORED SURFACE PIRELLI (IT) 2014-06-04 EP disclosed
US-20120277423-A1 PROTEIN CROSSLINKING INHIBITOR AND USE OF THE SAME JAPAN SCIENCE AND TECHNOLOGY AGENCY 2012-11-01 US disclosed
US-20120277423-A1 PROTEIN CROSSLINKING INHIBITOR AND USE OF THE SAME JAPAN SCIENCE AND TECHNOLOGY AGENCY 2012-11-01 US disclosed
US-20120277423-A1 PROTEIN CROSSLINKING INHIBITOR AND USE OF THE SAME JAPAN SCIENCE AND TECHNOLOGY AGENCY 2012-11-01 US disclosed
US-8196627-B2 Tire having a coated surface PIRELLI TYRE S.P.A. (IT) 2012-06-12 US disclosed
US-8151848-B2 Tire having a colored surface PIRELLI TYRE S.P.A. (IT) 2012-04-10 US disclosed
EP-1660507-B9 PROTEASOME INHIBITORS AND METHODS OF USING THE SAME CEPHALON INC (US) 2010-03-24 EP disclosed
US-20100024942-A1 Tire Having a Colored Surface PIRELLI TYRE S.P.A. (IT) 2010-02-04 US disclosed
EP-2021420-B1 TIRE HAVING A COATED SURFACE PIRELLI (IT) 2009-10-21 EP disclosed
US-20090250150-A1 Tire having a coated surface PIRELLI TYRE S.P.A. (IT) 2009-10-08 US disclosed
US-20090221645-A1 Dihydroimidazothiazole Derivatives PROSIDION LIMITED (GB) 2009-09-03 US disclosed
US-20090221645-A1 Dihydroimidazothiazole Derivatives PROSIDION LIMITED (GB) 2009-09-03 US disclosed
US-20090221645-A1 Dihydroimidazothiazole Derivatives PROSIDION LIMITED (GB) 2009-09-03 US disclosed
EP-1660507-B1 PROTEASOME INHIBITORS AND METHODS OF USING THE SAME CEPHALON INC (US) 2009-08-05 EP disclosed
EP-2021420-A1 TIRE HAVING A COATED SURFACE Pirelli Tyre S.p.A. (IT) 2009-02-11 EP disclosed
EP-1963387-A1 TIRE HAVING A COLORED SURFACE PIRELLI TYRE S.p.A. (IT) 2008-09-03 EP disclosed
WO-2007137608-A1 TIRE HAVING A COATED SURFACE PIRELLI TYRE S.P.A. (IT) 2007-12-06 WO disclosed
EP-1851232-A2 DIHYDROIMIDAZOTHIAZOLE DERIVATIVES Prosidion Limited (GB) 2007-11-07 EP disclosed
WO-2007071272-A1 TIRE HAVING A COLORED SURFACE PIRELLI TYRE S.P.A. (IT) 2007-06-28 WO disclosed
WO-2006085118-A2 DIHYDROIMIDAZOTHIAZOLE DERIVATIVES PROSIDION LIMITED (GB) 2006-08-17 WO disclosed
EP-1421071-A2 SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS NOVO NORDISK A/S (DK) 2004-05-26 EP disclosed
EP-1045846-B1 IMIDAZOLE DERIVATIVES HAVING AN INHIBITORY ACTIVITY FOR FARNESYL TRANSFERASE AND PROCESS FOR PREPARATION THEREOF LG CHEMICAL LTD (KR) 2003-05-02 EP disclosed
US-6518429-B2 Anticancer agents, treating restenosis, atherosclerosis and hepatitis virus LG CHEMICAL, LTD. (KR) 2003-02-11 US disclosed
WO-2003004480-A2 SUBSTITUTED PIPERAZINE AND DIAZEPANES AS HISTAMINE H3 RECEPTOR AGONISTS NOVO NORDISK A/S (DK) 2003-01-16 WO disclosed
EP-1058683-B1 FARNESYL TRANSFERASE INHIBITORS HAVING A PIPERIDINE STRUCTURE AND PROCESS FOR PREPARATION THEREOF LG CHEMICAL LTD (KR) 2002-12-04 EP disclosed
US-6472526-B1 SHOWS AN INHIBITORY ACTIVITY AGAINST FARNESYL TRANSFERASE OR PHARMACEUTICALLY ACCEPTABLE SALTS OR ISOMERS THEREOF, IN PHARMACEUTICAL COMPOSITION AND INTERMEDIATES LG CHEMICAL LTD. (KR) 2002-10-29 US disclosed
US-20020137769-A1 Imidazole derivatives having an inhibitory activity for farnesyl transferase and process for preparation thereof LG CHEMICAL LTD. 2002-09-26 US disclosed
US-6436960-B1 TREATING CANCER, RESTENOSIS, ATHEROSCLEROSIS AND INFECTIONS FROM HEPATITIS DELTA AND RELATED VIRUSES. LG CHEMICAL LTD. (KR) 2002-08-20 US disclosed
US-6268363-B1 ANTITUMOR LG CHEMICAL LTD. (KR) 2001-07-31 US disclosed
EP-1058683-A1 FARNESYL TRANSFERASE INHIBITORS HAVING A PIPERIDINE STRUCTURE AND PROCESS FOR PREPARATION THEREOF LG CHEMICAL LIMITED (KR) 2000-12-13 EP disclosed
EP-1045846-A1 IMIDAZOLE DERIVATIVES HAVING AN INHIBITORY ACTIVITY FOR FARNESYL TRANSFERASE AND PROCESS FOR PREPARATION THEREOF LG CHEMICAL LIMITED (KR) 2000-10-25 EP disclosed
WO-1999038862-A1 FARNESYL TRANSFERASE INHIBITORS HAVING A PIPERIDINE STRUCTURE AND PROCESS FOR PREPARATION THEREOF LG CHEMICAL LTD. (KR) 1999-08-05 WO disclosed
WO-1999028315-A1 IMIDAZOLE DERIVATIVES HAVING AN INHIBITORY ACTIVITY FOR FARNESYL TRANSFERASE AND PROCESS FOR PREPARATION THEREOF LG CHEMICAL LTD. (KR) 1999-06-10 WO disclosed
EP-0015750-B1 1-(NAPHTHYL-N-PROPYL)IMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, METHODS OF MAKING THEM AND THEIR USE FOR PHARMACEUTICALS SYNTEX (U.S.A.) INC. (US) 1982-11-24 EP disclosed
US-4293561-A ANTICONVULSANT ANTISECRETORY AGENTS SYNTEX (U.S.A.) INC. (US) 1981-10-06 US disclosed
EP-0015750-A1 1-(Naphthyl-n-propyl)imidazole derivatives, compositions containing them, methods of making them and their use for pharmaceuticals SYNTEX (U.S.A.) INC. (US) 1980-09-17 EP disclosed
US-4116869-A POLYMERIZATION PHILLIPS PETROLEUM COMPANY (US) 1978-09-26 US disclosed
US-4095017-A VINYL MONOMER POLYMERIZATION OR COPOLYMERIZATION CATALYZED BY ORGANOALUMINUM-ORGANOPHOSPHINE-METAL SALT OF A BETA-DIKETONE CATALYST SYSTEM PHILLIPS PETROLEUM COMPANY (US) 1978-06-13 US disclosed
US-4061638-A Organocalciumpyridine-type polymerization initiators PHILLIPS PETROLEUM COMPANY (US) 1977-12-06 US disclosed
US-4020018-A Alkene oxide or acrylate polymerization or copolymerization catalyzed by organoaluminum-organophosphine-metal salt of a beta-diketone PHILLIPS PETROLEUM COMPANY (US) 1977-04-26 US disclosed
US-3997708-A ADDITION PHILLIPS PETROLEUM COMPANY (US) 1976-12-14 US disclosed
US-3984599-A MINERAL OIL, WAXES, WAX CRYSTAL MODIFIER EXXON RESEARCH AND ENGINEERING COMPANY (US) 1976-10-05 US disclosed
US-3932573-A Process for producing glass fiber reinforced injection molding compounds ETHYL CORPORATION (US) 1976-01-13 US disclosed
US-3932573-A Process for producing glass fiber reinforced injection molding compounds ETHYL CORPORATION (US) 1976-01-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090221645-A1 Dihydroimidazothiazole Derivatives TPH1, HTR3B, HTR1A NR4A1 498/4885NR4A2 544/4885NR4A3 463/4885
US-20020137769-A1 Imidazole derivatives having an inhibitory activity for farnesyl transferase and process for preparation thereof FNTA, FNTB, FDPS NR4A1 4040/4885NR4A2 4225/4885NR4A3 3972/4885
US-20120277423-A1 PROTEIN CROSSLINKING INHIBITOR AND USE OF THE SAME ARGLU1, F12, CDKL1 NR4A1 4317/4885NR4A2 4218/4885NR4A3 4160/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.