Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 10/20 | 0.62 |
| ▸ | HTR2C | P28335 | 8/20 | 0.62 |
| ▸ | HTR2B | P41595 | 6/20 | 0.62 |
| ▸ | HTR2A | P28223 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 7/20 | 0.43 |
| ▸ | KDM1A | O60341 | 6/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.43 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7527758 | 0.98 | MAOB (0.63) | MAOBHTR2CHTR2BHTR2AMEN1 | |
| SCHEMBL15254847 | 0.96 | MAOB (0.62) | MAOBHTR2CHTR2BHTR2AMAOA | |
| SCHEMBL15590759 | 0.88 | MAOB (0.67) | MAOBHTR2CHTR2BHTR2AMAOA | |
| SCHEMBL6030936 | 0.81 | KDM1A (0.43) | MAOBHTR2CHTR2BHTR2AKDM1A | |
| SCHEMBL23185437 | 0.80 | MEN1 (0.46) | MAOBHTR2CHTR2BHTR2AMEN1 | |
| SCHEMBL839081 | 0.80 | MEN1 (0.50) | MAOBHTR2CHTR2BHTR2AMEN1 | |
| SCHEMBL12020671 | 0.79 | HTR2A (0.67) | HTR2CHTR2BHTR2ASLC6A3 | |
| SCHEMBL12020812 | 0.79 | HTR2A (0.67) | HTR2CHTR2BHTR2ASLC6A3 | |
| SCHEMBL726305 | 0.79 | HTR2A (0.67) | HTR2CHTR2BHTR2ASLC6A3 | |
| SCHEMBL1841583 | 0.79 | HTR2A (0.67) | HTR2CHTR2BHTR2ASLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686984-B1 | USE OF C-(2-PHENYL-CYCLOHEXYL)-METHYLAMINE COMPOUNDS FOR THE TREATMENT OF ANXIETY DISORDERS | GRUENENTHAL GMBH (DE) | 2011-05-18 | — | — | EP | claimed |
| US-20100249225-A1 | C-(2-Phenyl-Cyclohexyl)-Methylamine Compounds for the Treatment of Anxiety Disorders | GRUENENTHAL GMBH (DE) | 2010-09-30 | — | — | US | claimed |
| US-20060258741-A1 | C-(2-phenyl-cyclohexyl)-methylamine compounds for the treatment of anxiety disorders | GRUENENTHAL GMBH | 2006-11-16 | — | — | US | claimed |
| EP-1970060-B9 | Use of C-(2-Phenyl-cyclohexyl)-methylamine compounds for fibromyalgia therapy | GRUENENTHAL GMBH (DE) | 2013-01-09 | — | — | EP | disclosed |
| EP-1970060-B1 | Use of C-(2-Phenyl-cyclohexyl)-methylamine compounds for fibromyalgia therapy | GRUENENTHAL GMBH (DE) | 2012-08-29 | — | — | EP | disclosed |
| US-8084497-B2 | C-(2-phenyl-cyclohexyl)-methylamine compounds for therapy of fibromyalgia | GRUENENTHAL GMBH (DE) | 2011-12-27 | — | — | US | disclosed |
| US-20110295038-A1 | Process for the Preparation of Substituted 1-aminomethyl-2-phenyl-cyclohexane Compounds | GRUENENTHAL GMBH (DE) | 2011-12-01 | — | — | US | disclosed |
| US-20110295038-A1 | Process for the Preparation of Substituted 1-aminomethyl-2-phenyl-cyclohexane Compounds | GRUENENTHAL GMBH (DE) | 2011-12-01 | — | — | US | disclosed |
| US-20110295038-A1 | Process for the Preparation of Substituted 1-aminomethyl-2-phenyl-cyclohexane Compounds | GRUENENTHAL GMBH (DE) | 2011-12-01 | — | — | US | disclosed |
| WO-2011147576-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED 1-AMINOMETHYL-2-PHENYL-CYCLOHEXANE COMPOUNDS | Grünenthal GmbH (DE) | 2011-12-01 | — | — | WO | disclosed |
| WO-2011147576-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED 1-AMINOMETHYL-2-PHENYL-CYCLOHEXANE COMPOUNDS | Grünenthal GmbH (DE) | 2011-12-01 | — | — | WO | disclosed |
| US-20100249225-A1 | C-(2-Phenyl-Cyclohexyl)-Methylamine Compounds for the Treatment of Anxiety Disorders | GRUENENTHAL GMBH (DE) | 2010-09-30 | — | — | US | disclosed |
| US-20100004341-A1 | C-(2-Phenyl-Cyclohexyl)-Methylamine Compounds for Therapy of Fibromyalgia | GRUENENTHAL GMBH (DE) | 2010-01-07 | — | — | US | disclosed |
| EP-1970060-A3 | Use of C-(2-Phenyl-cyclohexyl)-methylamine compounds for fibromyalgia therapy | Grünenthal GmbH (DE) | 2009-04-15 | — | — | EP | disclosed |
| EP-1970060-A2 | Use of C-(2-Phenyl-cyclohexyl)-methylamine compounds for fibromyalgia therapy | Grünenthal GmbH (DE) | 2008-09-17 | — | — | EP | disclosed |
| EP-1970060-A2 | Use of C-(2-Phenyl-cyclohexyl)-methylamine compounds for fibromyalgia therapy | Grünenthal GmbH (DE) | 2008-09-17 | — | — | EP | disclosed |
| US-20060258741-A1 | C-(2-phenyl-cyclohexyl)-methylamine compounds for the treatment of anxiety disorders | GRUENENTHAL GMBH | 2006-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060258741-A1 | C-(2-phenyl-cyclohexyl)-methylamine compounds for the treatment of anxiety disorders | PNMT, HTR2C, HTR2A | MAOB 32/4885HTR2C 2/4885HTR2B 14/4885 |
| US-20100004341-A1 | C-(2-Phenyl-Cyclohexyl)-Methylamine Compounds for Therapy of Fibromyalgia | PNMT, HNMT, GNMT | MAOB 42/4885HTR2C 11/4885HTR2B 46/4885 |
| US-20100249225-A1 | C-(2-Phenyl-Cyclohexyl)-Methylamine Compounds for the Treatment of Anxiety Disorders | PNMT, HTR2C, HTR2A | MAOB 32/4885HTR2C 2/4885HTR2B 14/4885 |
| US-20110295038-A1 | Process for the Preparation of Substituted 1-aminomethyl-2-phenyl-cyclohexane Compounds | ADRM1, PNMT, ACMSD | MAOB 81/4885HTR2C 322/4885HTR2B 748/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.