Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 9/20 | 0.34 |
| ▸ | IDH1 | O75874 | 3/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.30 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.30 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.30 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.30 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.30 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CCR5 | P51681 | 1/20 | 0.30 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.30 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9236157 | 0.82 | MGAM (0.34) | MDM2 | |
| SCHEMBL7262995 | 0.82 | SIGMAR1 (0.35) | MDM2 | |
| SCHEMBL7898909 | 0.82 | S1PR3 (0.39) | MEN1KMT2A | |
| SCHEMBL6835149 | 0.76 | LMNA (0.34) | MDM2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7893124 | 0.72 | ABCB1 (0.37) | MEN1ALDH1A1KMT2AMTNR1AMTNR1B | |
| SCHEMBL7892968 | 0.71 | ABCB1 (0.40) | — | |
| SCHEMBL7892970 | 0.71 | ABCB1 (0.40) | — | |
| SCHEMBL22636048 | 0.71 | ELANE (0.35) | IDH1MEN1ALDH1A1KMT2A | |
| SCHEMBL6918361 | 0.71 | ELANE (0.35) | IDH1MEN1ALDH1A1KMT2A | |
| SCHEMBL9238321 | 0.71 | PTGDR2 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6319702-B1 | NUCLEOTIDE SEQUENCS CODING AN ENZYMATIC POLYPEPTIDE AND CELL TARGETING COMPOUND; FOR USE IN TREATMENT OF CANCER | GLAXO WELLCOME, INC. | 2001-11-20 | — | — | US | disclosed |