SCHEMBL726424

SCHEMBL726424

Cc1cc(C)cc(-c2cc(O)ccc2Cc2ccc(O)cc2-c2cc(C)cc(C)c2)c1

nearest known ligand 0.40

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 5/20 0.40
CNR2 P34972 5/20 0.40
ALDH1A1 P00352 1/20 0.39
AMY1A P0DUB6 1/20 0.39
TYR P14679 2/20 0.38
IDH1 O75874 3/20 0.36
ESR2 Q92731 3/20 0.36
HSD17B1 P14061 1/20 0.36
HSD17B2 P37059 1/20 0.36
HSPA5 P11021 1/20 0.35
ALOX5 P09917 1/20 0.35
ESR1 P03372 2/20 0.35
ACHE P22303 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1857743 0.87 ANPEP (0.41) CNR1CNR2ALDH1A1TYRIDH1
SCHEMBL1858269 0.84 TYR (0.43) CNR1CNR2ALDH1A1TYRESR2
SCHEMBL8829920 0.83 CA1 (0.46) AMY1ATYRESR2ALOX5ESR1
SCHEMBL27566464 0.81 CNR1 (0.44) CNR1CNR2ALDH1A1TYRIDH1
SCHEMBL1857824 0.80 CYP3A4 (0.57) CNR1CNR2ALDH1A1TYRALOX5
SCHEMBL1858833 0.79 NR3C1 (0.38) CNR1CNR2ALDH1A1TYRESR2
SCHEMBL27658836 0.78 ALDH1A1 (0.44) CNR1CNR2ALDH1A1ESR2HSD17B1
SCHEMBL1860042 0.78 ALDH1A1 (0.44) CNR1CNR2ALDH1A1AMY1ATYR
SCHEMBL27092591 0.77 ACHE (0.44) AMY1AESR2ESR1ACHE
SCHEMBL11207723 0.76 ALOX5 (0.57) ALDH1A1ESR2ALOX5ESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 281 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1660560-B1 PHASE TRANSFER CATALYZED METHOD FOR PREPARATION OF POLYETEHRIMIDES SABIC GLOBAL TECHNOLOGIES BV (NL) 2016-03-23 EP claimed
JP-4768635-B2 2011-09-07 JP claimed
EP-1546249-B1 FLAME RETARDANT RESINOUS COMPOSITIONS AND METHOD SABIC INNOVATIVE PLASTICS IP (NL) 2011-03-16 EP claimed
US-7714095-B2 Phase transfer catalyzed method for preparation of polyetherimides SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2010-05-11 US claimed
JP-2009521548-A 2009-06-04 JP claimed
EP-1660556-B1 COPOLYETHERIMIDES SABIC INNOVATIVE PLASTICS IP (NL) 2009-05-13 EP claimed
EP-1989246-A2 PHASE TRANSFER CATALYZED METHOD FOR PREPARATION OF POLYETHERIMIDES Sabic Innovative Plastics IP B.V. (NL) 2008-11-12 EP claimed
EP-1966320-A2 HIGH GLASS TRANSITION TEMPERATURE THERMOPLASTIC ARTICLES General Electric Company (US) 2008-09-10 EP claimed
EP-1963433-A2 ANNULAR OR TUBULAR SHAPED ARTICLES OF NOVEL POLYMER BLENDS General Electric Company (US) 2008-09-03 EP claimed
EP-1963432-A1 EXPANDED AND EXPANDABLE HIGH GLASS TRANSITION TEMPERATURE POLYMERS General Electric Company (US) 2008-09-03 EP claimed
WO-2005021618-A2 PHASE TRANSFER CATALYZED METHOD FOR PREPARATION OF POLYETEHRIMIDES GENERAL ELECTRIC COMPANY (US) 2005-03-10 WO claimed
WO-2005021477-A2 METHOD FOR MAKING SALTS OF HYDROXY-SUBSTITUTED HYDROCARBONS GENERAL ELECTRIC COMPANY (US) 2005-03-10 WO claimed
US-20050049390-A1 Phase transfer catalyzed method for preparation of polyetherimides GENERAL ELECTRIC COMPANY 2005-03-03 US claimed
US-20050049439-A1 Method for making salts hydroxy-substituted hydrocarbons GENERAL ELECTRIC COMPANY 2005-03-03 US claimed
US-6849706-B1 Copolyetherimides GENERAL ELECTRIC COMPANY (US) 2005-02-01 US claimed
US-6713598-B2 FLAME RETARDANT WITH SPECIFIED MOLECULAR WEIGHT AND SOFTENING TEMPERATURE; REACTING PHOSPHORUS OXYHALIDE WITH HYDROXYAROMATIC COMPOUND, REACTING ARYLDIHALOPHOSPHATE WITH DIHYDROXYAROMATIC, THEN WITH HYDROXYAROMATIC GENERAL ELECTRIC COMPANY 2004-03-30 US claimed
US-20040044134-A1 METHOD TO MAKE A SOLID POLYMERIC PHOSPHATE AND RESINOUS COMPOSITIONS CONTAINING IT GENERAL ELECTRIC COMPANY 2004-03-04 US claimed
WO-2004016685-A2 FLAME RETARDANT RESINOUS COMPOSITIONS AND METHOD GENERAL ELECTRIC COMPANY (US) 2004-02-26 WO claimed
US-20040034132-A1 Flame retardant resinous compositions and method GENERAL ELECTRIC COMPANY 2004-02-19 US claimed
US-20040014934-A1 Method for the production of polyestercarbonates GENERAL ELECTRIC COMPANY 2004-01-22 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050049439-A1 Method for making salts hydroxy-substituted hydrocarbons HDHD5, SHH, HAAO CNR1 1654/4885CNR2 2147/4885ALDH1A1 2467/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.