Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 6/20 | 0.40 |
| ▸ | METAP1 | P53582 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7316351 | 0.83 | NPC1 (0.55) | KMT2AMEN1ALDH1A1 | |
| SCHEMBL7265331 | 0.83 | KMT2A (0.46) | METAP2METAP1SIGMAR1KMT2AKDM4E | |
| SCHEMBL7318507 | 0.82 | NPC1 (0.40) | SIGMAR1KMT2AMEN1 | |
| SCHEMBL7370031 | 0.81 | GRM2 (0.36) | KMT2AMEN1 | |
| SCHEMBL7316783 | 0.80 | P2RX7 (0.43) | SIGMAR1KMT2AMEN1MAPT | |
| SCHEMBL7319239 | 0.78 | NPC1 (0.41) | KMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL7321024 | 0.77 | RAB9A (0.46) | KMT2AALDH1A1PKM | |
| SCHEMBL7318543 | 0.76 | SMN1; SMN2 (0.47) | SIGMAR1KMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL10584481 | 0.75 | NPC1 (0.38) | KMT2AMEN1 | |
| SCHEMBL7293796 | 0.74 | KMT2A (0.45) | METAP2METAP1SIGMAR1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0280956-B1 | THIAZOLIDINE DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 1992-10-21 | — | — | EP | claimed |
| US-4857537-A | PREVENTING AMNESIA | ONO PHARMACEUTICAL CO., LTD. (JP) | 1989-08-15 | — | — | US | claimed |
| EP-0280956-A1 | Thiazolidine derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1988-09-07 | — | — | EP | claimed |