Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.41 |
| ▸ | HTR3B | O95264 | 2/20 | 0.41 |
| ▸ | HTR3A | P46098 | 2/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.41 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.30 |
| ▸ | CTSS | P25774 | 1/20 | 0.30 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7272916 | 0.81 | HTR3E (0.46) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7274925 | 0.81 | HTR3E (0.43) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7297785 | 0.80 | HTR3E (0.42) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7272061 | 0.74 | HTR3A (0.45) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| Maleic Acid SCHEMBL7265485 | 0.74 | GABRR1 (0.41) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| Fumaric Acid SCHEMBL7265493 | 0.74 | GABRR1 (0.41) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7286830 | 0.72 | HTR3A (0.72) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| Maleic Acid SCHEMBL7265488 | 0.71 | HTR3E (0.65) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL9656646 | 0.71 | GABRR1 (0.41) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7273229 | 0.65 | KDM4E (0.36) | HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276163-B1 | INDOLE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1992-07-15 | — | — | EP | disclosed |
| US-4808581-A | ANXIOLYTIC, ANTIEMETIC, TREATMENT OF PSYCHOLOGICAL DISORDERS | GLAXO GROUP LIMITED (GB) | 1989-02-28 | — | — | US | disclosed |
| EP-0276163-A2 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1988-07-27 | — | — | EP | disclosed |