Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 3/20 | 0.32 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7276249 | 0.95 | HTR4 (0.39) | HTR4HTR3AKAT2B | |
| SCHEMBL7267544 | 0.84 | PGK1 (0.33) | HTR3AHCAR3CHRNB4CHRNA3KAT2B | |
| SCHEMBL7266786 | 0.76 | GPR139 (0.39) | — | |
| SCHEMBL7267651 | 0.76 | HTR4 (0.31) | HTR4ADORA2A | |
| SCHEMBL7267645 | 0.76 | HTR4 (0.31) | HTR4ADORA2A | |
| SCHEMBL7268093 | 0.74 | HTR4 (0.39) | HTR4HTR3AKAT2B | |
| SCHEMBL7273660 | 0.71 | — | — | |
| SCHEMBL7266973 | 0.70 | ALDH1A1 (0.49) | HTR3AMAPK1 | |
| SCHEMBL7273132 | 0.67 | PIK3CA (0.33) | — | |
| SCHEMBL2824624 | 0.63 | KDM4E (0.40) | HCAR3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0315390-B1 | Novel 4-oxobenzotriazines and 4-oxoquinazolines | BEECHAM GROUP PLC (GB) | 1994-07-20 | — | — | EP | claimed |
| US-4959367-A | ANALGESICS, TRANQUILIZERS, GASTROINTESTINAL, CNS | BEECHAM GROUP P.L.C. (GB) | 1990-09-25 | — | — | US | claimed |
| EP-0315390-A2 | Novel 4-oxobenzotriazines and 4-oxoquinazolines | BEECHAM GROUP PLC (GB) | 1989-05-10 | — | — | EP | claimed |
| EP-0315390-B1 | Novel 4-oxobenzotriazines and 4-oxoquinazolines | BEECHAM GROUP PLC (GB) | 1994-07-20 | — | — | EP | disclosed |
| EP-0315390-A2 | Novel 4-oxobenzotriazines and 4-oxoquinazolines | BEECHAM GROUP PLC (GB) | 1989-05-10 | — | — | EP | disclosed |