Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 17/20 | 0.46 |
| ▸ | PGC | P20142 | 1/20 | 0.44 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.41 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.41 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.41 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.41 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7268413 | 0.92 | CTSK (0.38) | RENPGC | |
| SCHEMBL7268374 | 0.86 | REN (0.41) | RENPGC | |
| SCHEMBL7370857 | 0.83 | REN (0.54) | RENPGC | |
| SCHEMBL7443816 | 0.80 | REN (0.55) | RENPGC | |
| SCHEMBL9725846 | 0.79 | REN (0.53) | RENPGC | |
| SCHEMBL9725848 | 0.79 | REN (0.53) | RENPGC | |
| SCHEMBL7271925 | 0.79 | REN (0.57) | RENPGC | |
| SCHEMBL7386767 | 0.79 | REN (0.57) | RENPGC | |
| SCHEMBL9526718 | 0.79 | REN (0.56) | RENPGC | |
| SCHEMBL9831316 | 0.79 | REN (0.49) | RENPGC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0376040-A2 | N-phosphinyl di-and tripeptides as renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1990-07-04 | — | — | EP | disclosed |