Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.38 |
| ▸ | CTSS | P25774 | 2/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.35 |
| ▸ | REN | P00797 | 13/20 | 0.35 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
| ▸ | CTSE | P14091 | 1/20 | 0.34 |
| ▸ | PGC | P20142 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7268382 | 0.92 | REN (0.46) | RENPGC | |
| SCHEMBL9740788 | 0.84 | POLB (0.34) | CTSK | |
| SCHEMBL7268400 | 0.81 | CTSK (0.34) | CTSKCTSSAAK1RENCTSD | |
| SCHEMBL10421180 | 0.81 | CTSS (0.42) | CTSKCTSSAAK1RENCTSD | |
| SCHEMBL7268374 | 0.78 | REN (0.41) | RENPGC | |
| SCHEMBL10711387 | 0.75 | CTSS (0.37) | CTSKCTSSAAK1RENPGC | |
| SCHEMBL7268409 | 0.75 | POLB (0.30) | — | |
| SCHEMBL10421240 | 0.75 | REN (0.46) | RENCTSDCTSEPGC | |
| SCHEMBL7370857 | 0.73 | REN (0.54) | RENPGC | |
| SCHEMBL7333295 | 0.72 | REN (0.46) | RENCTSDCTSEPGC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0376040-A2 | N-phosphinyl di-and tripeptides as renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1990-07-04 | — | — | EP | disclosed |