Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8009812 | 0.88 | NPC1 (0.53) | NPC1RAB9AALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL21107863 | 0.84 | ALDH1A1 (0.49) | NPC1RAB9AALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL15937185 | 0.81 | BCHE (0.45) | NPC1RAB9AALDH1A1KMT2AMAPT | |
| SCHEMBL7509877 | 0.81 | HTT (0.60) | L3MBTL1LMNAKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL21069881 | 0.81 | ALDH1A1 (0.49) | NPC1RAB9AALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL21070425 | 0.81 | ALDH1A1 (0.49) | NPC1RAB9AALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL1177836 | 0.80 | ALDH1A1 (0.73) | ALDH1A1L3MBTL1MAPK1LMNAKMT2A | |
| SCHEMBL7448281 | 0.80 | RAB9A (0.47) | NPC1RAB9AALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL316882 | 0.80 | ALDH1A1 (0.55) | ALDH1A1L3MBTL1MAPK1LMNAKMT2A | |
| SCHEMBL27493267 | 0.79 | ALDH1A1 (0.61) | NPC1RAB9AALDH1A1L3MBTL1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5158970-A | Prolylendopeplidase inhibitors; antiamnesia | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 1992-10-27 | — | — | US | disclosed |
| EP-0384341-A2 | New proline derivatives | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 1990-08-29 | — | — | EP | disclosed |