Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1767096 | 0.85 | RAB9A (0.41) | NAPRTALDH1A1TDP1SHMT2HDAC6 | |
| SCHEMBL27670976 | 0.83 | KDM4E (0.43) | NAPRTALDH1A1TDP1KDM4EHDAC6 | |
| SCHEMBL4634043 | 0.80 | TDP1 (0.42) | NAPRTALDH1A1TDP1KDM4EHDAC6 | |
| SCHEMBL18989973 | 0.79 | ESR1 (0.39) | NAPRTALDH1A1RAB9AL3MBTL1MAPT | |
| SCHEMBL2304200 | 0.78 | FTO (0.41) | NAPRTALDH1A1TDP1KDM4EHDAC8 | |
| SCHEMBL377461 | 0.78 | LMNA (0.42) | NAPRTALDH1A1TDP1KDM4EHDAC6 | |
| SCHEMBL9850857 | 0.78 | ALOX15 (0.46) | NAPRTALDH1A1KDM4ESHMT2L3MBTL1 | |
| SCHEMBL18989937 | 0.78 | KDM4E (0.43) | NAPRTALDH1A1TDP1KDM4ERAB9A | |
| SCHEMBL3785068 | 0.77 | TDP1 (0.38) | NAPRTALDH1A1TDP1KDM4EHDAC6 | |
| SCHEMBL10448630 | 0.77 | SMN1; SMN2 (0.44) | ALDH1A1TDP1KDM4ERAB9ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001085715-A2 | AZA- AND POLYAZANTHRANYL AMIDES AND THEIR USE AS MEDICAMENTS | NOVARTIS AG (CH) | 2001-11-15 | — | — | WO | disclosed |
| EP-0059391-A1 | Imidazodiazepines, process for their preparation and pharmaceutical compositions containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-09-08 | — | — | EP | disclosed |