Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 4/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | MMP14 | P50281 | 1/20 | 0.50 |
| ▸ | MME | P08473 | 6/20 | 0.49 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.48 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.48 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.48 |
| ▸ | CPA1 | P15085 | 2/20 | 0.48 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | FPR2 | P25090 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7281772 | 0.87 | TACR1 (0.50) | ACEMMP9MMP8MMP14 | |
| SCHEMBL6895655 | 0.85 | ITGA4 (0.54) | ACEMMEPSMB1PSMB5PSMB2 | |
| SCHEMBL9068639 | 0.82 | ALDH1A1 (0.53) | MMEPSMB1PSMB5PSMB2LMNA | |
| SCHEMBL7283853 | 0.82 | ALDH1A1 (0.53) | MMEPSMB1PSMB5PSMB2LMNA | |
| SCHEMBL7282932 | 0.82 | ALDH1A1 (0.53) | MMEPSMB1PSMB5PSMB2LMNA | |
| SCHEMBL7273085 | 0.81 | CA12 (0.52) | ACEMMEPSMB1PSMB5PSMB2 | |
| SCHEMBL16195620 | 0.80 | MME (0.58) | ACEMMP9MMP8MMP14MME | |
| SCHEMBL7283028 | 0.80 | TACR2 (0.54) | MMP8MMELMNATDP1 | |
| SCHEMBL7279559 | 0.80 | POLB (0.46) | ACEMMEPSMB1PSMB5PSMB2 | |
| SCHEMBL6891310 | 0.80 | L3MBTL1 (0.46) | ACEMMEPSMB1PSMB5PSMB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5491132-A | HYPOTENSIVE AGENT | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-02-13 | — | — | US | disclosed |
| EP-0476515-A1 | New amino acid derivatives, a process for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-03-25 | — | — | EP | disclosed |