Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | CA9 | Q16790 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MME | P08473 | 5/20 | 0.46 |
| ▸ | ACE | P12821 | 2/20 | 0.46 |
| ▸ | CPA1 | P15085 | 1/20 | 0.45 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | FPR2 | P25090 | 3/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.43 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.43 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7273716 | 0.88 | TACR1 (0.47) | ACE | |
| SCHEMBL6895655 | 0.82 | ITGA4 (0.54) | CA12CA1CA9LMNAMME | |
| SCHEMBL7271561 | 0.81 | ACE (0.50) | CA12CA1CA9LMNAMME | |
| SCHEMBL7272209 | 0.77 | MME (0.57) | CA12CA1CA9LMNAMME | |
| SCHEMBL16195620 | 0.77 | MME (0.58) | LMNAMMEACECPA1ACE2 | |
| SCHEMBL27541800 | 0.77 | L3MBTL1 (0.46) | CA12CA1CA9LMNAMME | |
| SCHEMBL6891310 | 0.77 | L3MBTL1 (0.46) | CA12CA1CA9LMNAMME | |
| SCHEMBL7283853 | 0.76 | ALDH1A1 (0.53) | LMNAMMEFPR2PSMB1PSMB5 | |
| SCHEMBL7282932 | 0.76 | ALDH1A1 (0.53) | LMNAMMEFPR2PSMB1PSMB5 | |
| SCHEMBL9068639 | 0.76 | ALDH1A1 (0.53) | LMNAMMEFPR2PSMB1PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5491132-A | HYPOTENSIVE AGENT | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-02-13 | — | — | US | disclosed |
| EP-0476515-A1 | New amino acid derivatives, a process for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-03-25 | — | — | EP | disclosed |