Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | PRKCA | P17252 | 2/20 | 0.47 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.47 |
| ▸ | TACR1 | P25103 | 2/20 | 0.46 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7271252 | 0.90 | GPR139 (0.51) | KMT2AMEN1L3MBTL1GPR139NPSR1 | |
| SCHEMBL7263518 | 0.84 | MAPK1 (0.51) | KMT2AMEN1L3MBTL1NPSR1SMN1; SMN2 | |
| SCHEMBL7265287 | 0.83 | CYP1A2 (0.46) | KMT2APRKCAPRKCDNPSR1SMN1; SMN2 | |
| SCHEMBL7264094 | 0.83 | ALDH1A1 (0.47) | L3MBTL1PRKCAPRKCDTACR1NPSR1 | |
| SCHEMBL10638027 | 0.82 | MAPT (0.53) | KMT2AMEN1L3MBTL1NPSR1SMN1; SMN2 | |
| SCHEMBL7270056 | 0.81 | NPSR1 (0.46) | KMT2AMEN1PRKCAPRKCDTACR1 | |
| SCHEMBL7264080 | 0.80 | CYP1A2 (0.45) | KMT2AMEN1PRKCAPRKCDNPSR1 | |
| SCHEMBL10641638 | 0.79 | RAB9A (0.54) | KMT2AMEN1L3MBTL1PRKCAPRKCD | |
| SCHEMBL10911592 | 0.78 | CES2 (0.45) | L3MBTL1PRKCAPRKCDNPSR1SMN1; SMN2 | |
| SCHEMBL7263517 | 0.78 | ADRB2 (0.53) | KMT2AMEN1L3MBTL1GPR139NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0067770-B1 | TREATMENT OF MIGRAINE WITH TROPYL BENZOATE DERIVATIVES | MERRELL DOW FRANCE ET CIE (FR) | 1992-01-15 | — | — | EP | claimed |
| US-4585866-A | Treatment of migraine with substituted tropyl benzoate derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-04-29 | — | — | US | claimed |
| EP-0067770-A2 | Treatment of migraine with tropyl benzoate derivatives | MERRELL DOW FRANCE ET CIE (FR) | 1982-12-22 | — | — | EP | claimed |
| EP-0067770-B1 | TREATMENT OF MIGRAINE WITH TROPYL BENZOATE DERIVATIVES | MERRELL DOW FRANCE ET CIE (FR) | 1992-01-15 | — | — | EP | disclosed |
| EP-0067770-A2 | Treatment of migraine with tropyl benzoate derivatives | MERRELL DOW FRANCE ET CIE (FR) | 1982-12-22 | — | — | EP | disclosed |