Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | BAP1 | Q92560 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7272107 | 0.88 | GAA (0.48) | GAAALDH1A1KDM4EGLAMEN1 | |
| SCHEMBL7282120 | 0.85 | ALDH1A1 (0.50) | GAAALDH1A1KDM4EGLAMEN1 | |
| SCHEMBL7271467 | 0.84 | KDM4E (0.41) | GAAALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL7278442 | 0.83 | ALDH1A1 (0.48) | GAAALDH1A1KDM4EGLAMEN1 | |
| SCHEMBL7282256 | 0.80 | ADORA3 (0.62) | ALDH1A1KDM4EMEN1KMT2AHPGD | |
| SCHEMBL7280478 | 0.77 | CACNA1F (0.55) | GAAALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL7282476 | 0.75 | NR3C2 (0.62) | MEN1KMT2AMAPTNR1I2LMNA | |
| SCHEMBL7278440 | 0.75 | ALDH1A1 (0.42) | GAAALDH1A1KDM4EGLAMEN1 | |
| SCHEMBL10367692 | 0.74 | NR1I2 (0.56) | GAAALDH1A1KDM4EGLAMEN1 | |
| SCHEMBL7272890 | 0.73 | LMNA (0.51) | GAAALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0114273-B1 | NEW PHARMACOLOGICALLY ACTIVE PYRAZOLOPYRIDINES | GRUPPO LEPETIT S.p.A. (IT) | 1991-11-06 | — | — | EP | disclosed |
| US-4954508-A | HYPOTENSIVE | GRUPPO LEPETIT S.P.A. (IT) | 1990-09-04 | — | — | US | disclosed |