Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 5/20 | 0.54 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.48 |
| ▸ | CACNA1F | O60840 | 4/20 | 0.47 |
| ▸ | CACNA1D | Q01668 | 4/20 | 0.47 |
| ▸ | CACNA1S | Q13698 | 4/20 | 0.47 |
| ▸ | CACNA1C | Q13936 | 4/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7273162 | 0.90 | ACHE (0.52) | ACHECACNA1BCACNA1FCACNA1DCACNA1S | |
| SCHEMBL7280076 | 0.89 | ACHE (0.51) | ACHECACNA1BCACNA1FCACNA1DCACNA1S | |
| SCHEMBL7279866 | 0.89 | ACHE (0.51) | ACHECACNA1BCACNA1FCACNA1DCACNA1S | |
| SCHEMBL7281990 | 0.87 | ADORA3 (0.58) | ACHECACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL7273692 | 0.87 | ACHE (0.56) | ACHECACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL7278678 | 0.85 | CACNA1F (0.70) | ACHECACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL3016370 | 0.81 | CACNA1F (0.66) | ACHECACNA1BCACNA1FCACNA1DCACNA1S | |
| SCHEMBL7282275 | 0.79 | CA1 (0.49) | ACHECACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL4261000 | 0.78 | MAPT (0.56) | ACHECACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL7278639 | 0.78 | TSHR (0.52) | ACHECACNA1FCACNA1DCACNA1SCACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0114273-B1 | NEW PHARMACOLOGICALLY ACTIVE PYRAZOLOPYRIDINES | GRUPPO LEPETIT S.p.A. (IT) | 1991-11-06 | — | — | EP | disclosed |
| US-4954508-A | HYPOTENSIVE | GRUPPO LEPETIT S.P.A. (IT) | 1990-09-04 | — | — | US | disclosed |