Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10665879 | 0.94 | MEN1 (0.59) | MEN1KMT2AHTTLMNATP53 | |
| SCHEMBL28144455 | 0.88 | KMT2A (0.53) | MEN1KMT2AHTTLMNACES2 | |
| SCHEMBL10464567 | 0.85 | CYP1A2 (0.41) | MEN1KMT2AHTTLMNATP53 | |
| SCHEMBL10434088 | 0.85 | CYP1A2 (0.41) | MEN1KMT2AHTTLMNATP53 | |
| SCHEMBL28224848 | 0.82 | MEN1 (0.79) | MEN1KMT2AHTTLMNACES2 | |
| SCHEMBL28931550 | 0.82 | AKR1C3 (0.47) | LMNAAKR1C3CYP3A4KDM4EMAPT | |
| SCHEMBL7271189 | 0.81 | ALDH1A1 (0.56) | MEN1KMT2ALMNAKDM4EMAPT | |
| SCHEMBL7273342 | 0.80 | CES2 (0.45) | MEN1KMT2ALMNACES2CES1 | |
| SCHEMBL14528490 | 0.80 | KMT2A (0.53) | MEN1KMT2ALMNACES2CES1 | |
| SCHEMBL7483326 | 0.80 | GLO1 (0.64) | MEN1KMT2AHTTLMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0114273-B1 | NEW PHARMACOLOGICALLY ACTIVE PYRAZOLOPYRIDINES | GRUPPO LEPETIT S.p.A. (IT) | 1991-11-06 | — | — | EP | disclosed |
| US-4954508-A | HYPOTENSIVE | GRUPPO LEPETIT S.P.A. (IT) | 1990-09-04 | — | — | US | disclosed |
| EP-0114273-A1 | New pharmacologically active pyrazolopyridines | GRUPPO LEPETIT S.p.A. (IT) | 1984-08-01 | — | — | EP | disclosed |