Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 2/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.58 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.58 |
| ▸ | P4HB | P07237 | 2/20 | 0.56 |
| ▸ | GSK3B | P49841 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | STS | P08842 | 1/20 | 0.51 |
| ▸ | VNN1 | O95497 | 7/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4201889 | 0.87 | ATM (0.63) | CLK1DYRK1ADYRK1BGSK3BVNN1 | |
| SCHEMBL9797519 | 0.85 | GSK3B (0.53) | CLK1DYRK1ADYRK1BGSK3BVNN1 | |
| SCHEMBL11445310 | 0.85 | VNN1 (0.61) | CLK1DYRK1ADYRK1BGSK3BVNN1 | |
| SCHEMBL6651723 | 0.85 | GSK3B (0.53) | CLK1DYRK1ADYRK1BGSK3BVNN1 | |
| SCHEMBL9856491 | 0.83 | GSK3B (0.54) | CLK1DYRK1ADYRK1BGSK3BVNN1 | |
| SCHEMBL5962921 | 0.81 | CA2 (0.70) | P4HBGSK3BLMNAMAPTHTT | |
| SCHEMBL698836 | 0.81 | LMNA (0.71) | CLK1DYRK1ADYRK1BLMNAMAPT | |
| SCHEMBL10395127 | 0.81 | LMNA (0.71) | CLK1DYRK1ADYRK1BLMNAMAPT | |
| SCHEMBL7780410 | 0.81 | VNN1 (0.63) | P4HBGSK3BLMNAMAPTHPGD | |
| SCHEMBL507406 | 0.81 | GSK3B (0.60) | GSK3BVNN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0483667-B1 | Cyclic imino derivatives, process for their preparation and drugs containing them | THOMAE GMBH DR K (DE) | 1998-02-04 | — | — | EP | disclosed |
| US-5668282-A | 4,5-cyclicimidazo[1,5-A]quinoxalines | PHARMACIA & UPJOHN COMPANY (US) | 1997-09-16 | — | — | US | disclosed |
| US-5591769-A | PYRROLIDINE DERIVATIVES; ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1997-01-07 | — | — | US | disclosed |
| US-5541343-A | ANTIAGGLOMERANTS FOR CELLS OR ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |
| EP-0288189-B1 | IMPROVEMENTS IN OR RELATING TO LEUKOTRIENE ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1992-11-11 | — | — | EP | disclosed |
| EP-0483667-A2 | Cyclic imino derivatives, process for their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1992-05-06 | — | — | EP | disclosed |
| US-4996347-A | Anticoagulant | FOURNIER INNOVATION ET SYNERGIE (FR) | 1991-02-26 | — | — | US | disclosed |
| US-4877808-A | ANTITHROMBOTICS | FOURNIER INNOVATION ET SYNERGIE (FR) | 1989-10-31 | — | — | US | disclosed |
| US-4853398-A | ANTIALLERGENS | ELI LILLY AND COMPANY (US) | 1989-08-01 | — | — | US | disclosed |
| EP-0288189-A1 | Improvements in or relating to leukotriene antagonists | ELI LILLY AND COMPANY (US) | 1988-10-26 | — | — | EP | disclosed |