SCHEMBL7274136

SCHEMBL7274136

N=C(N)NCCCCCC(=O)NC[C@@H]1C[C@@H](CC(=O)O)C(=O)N1CCc1ccc2ccccc2c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 8/20 0.39
HDAC8 Q9BY41 6/20 0.39
HDAC2 Q92769 7/20 0.38
HDAC3 O15379 6/20 0.38
MC4R P32245 1/20 0.36
MC5R P33032 1/20 0.36
MC3R P41968 1/20 0.36
MC1R Q01726 1/20 0.36
ASAH1 Q13510 1/20 0.36
ITGB3 P05106 1/20 0.35
ITGA2B P08514 1/20 0.35
CYP1A2 P05177 1/20 0.35
HCAR2 Q8TDS4 1/20 0.35
HDAC6 Q9UBN7 5/20 0.35
HDAC4 P56524 4/20 0.35
HDAC7 Q8WUI4 4/20 0.35
HDAC10 Q969S8 4/20 0.35
HDAC11 Q96DB2 4/20 0.35
HDAC9 Q9UKV0 4/20 0.35
HDAC5 Q9UQL6 4/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7274864 0.91 NAMPT (0.40) HDAC1HDAC8HDAC2HDAC3ITGB3
SCHEMBL7272799 0.90 HDAC1 (0.41) HDAC1HDAC8HDAC2HDAC3MC4R
SCHEMBL7284310 0.87 NAMPT (0.41) HDAC1HDAC8HDAC2HDAC3ITGB3
SCHEMBL7272971 0.87 NAMPT (0.41) HDAC1HDAC8HDAC2HDAC3ITGB3
SCHEMBL7272690 0.87 NAMPT (0.41) HDAC1HDAC8HDAC2HDAC3ITGB3
SCHEMBL7272983 0.87 GRB2 (0.37) HDAC1HDAC8HDAC2HDAC3MC4R
SCHEMBL7272852 0.86 SIGMAR1 (0.40) HDAC1HDAC8HDAC2HDAC3HDAC6
SCHEMBL7274469 0.86 LMNA (0.42) HDAC1HDAC8HDAC2HDAC3ITGB3
SCHEMBL7282847 0.84 HDAC3 (0.41) HDAC1HDAC8HDAC2HDAC3ITGB3
SCHEMBL7274533 0.83 TSHR (0.40) ITGB3ITGA2BCYP1A2F13A1F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5591769-A PYRROLIDINE DERIVATIVES; ANTICOAGULANTS KARL THOMAE GMBH (DE) 1997-01-07 US disclosed
US-5541343-A ANTIAGGLOMERANTS FOR CELLS OR ANTICOAGULANTS KARL THOMAE GMBH (DE) 1996-07-30 US disclosed
EP-0483667-A2 Cyclic imino derivatives, process for their preparation and drugs containing them Dr. Karl Thomae GmbH (DE) 1992-05-06 EP disclosed