Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 2/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.42 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7274867 | 0.93 | KDM4E (0.45) | KDM4EPKMFAAHGPR119FPR2 | |
| SCHEMBL7286397 | 0.83 | ACE (0.51) | ITGB3ITGA2BKDM4EPKMFAAH | |
| SCHEMBL7276724 | 0.83 | ACE (0.51) | ITGB3ITGA2BKDM4EPKMFAAH | |
| SCHEMBL8892804 | 0.80 | KDM4E (0.55) | KDM4EPKMFAAHGPR119HPGD | |
| SCHEMBL7277084 | 0.80 | FAAH (0.46) | KDM4EPKMFAAHGPR119HPGD | |
| SCHEMBL23212559 | 0.77 | HPGD (0.55) | KDM4EPKMFAAHGPR119HPGD | |
| SCHEMBL7277046 | 0.76 | GPR119 (0.45) | KDM4EPKMFAAHGPR119FPR2 | |
| SCHEMBL584378 | 0.76 | KDM4E (0.54) | KDM4EPKMFAAHGPR119HPGD | |
| SCHEMBL7274902 | 0.76 | ACE (0.49) | KDM4EPKMFAAHGPR119FPR2 | |
| SCHEMBL7367544 | 0.76 | KDM4E (0.46) | KDM4EPKMFAAHGPR119FPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0512831-B1 | Fibrinogen receptor antagonists | MERCK & CO INC (US) | 1999-09-22 | — | — | EP | disclosed |
| US-5455243-A | Anticoagulants | MERCK & CO., INC. (US) | 1995-10-03 | — | — | US | disclosed |
| US-5281585-A | Secondary amide containing antagonist | MERCK & CO., INC. (US) | 1994-01-25 | — | — | US | disclosed |
| WO-1992019595-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1992-11-12 | — | — | WO | disclosed |
| EP-0512831-A1 | Fibrinogen receptor antagonists | MERCK & CO. INC. (US) | 1992-11-11 | — | — | EP | disclosed |