Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | KDM5A | P29375 | 3/20 | 0.41 |
| ▸ | PHF8 | Q9UPP1 | 3/20 | 0.41 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | METAP1 | P53582 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7266729 | 0.94 | SIGMAR1 (0.47) | SIGMAR1GRM2GRM3CYP1A2KDM5A | |
| SCHEMBL528248 | 0.77 | CYP1A2 (0.47) | SIGMAR1CYP1A2KDM5APHF8KDM2A | |
| SCHEMBL8745906 | 0.74 | GRM2 (0.44) | SIGMAR1GRM2GRM3KDM5APHF8 | |
| SCHEMBL10701341 | 0.74 | GRM2 (0.44) | SIGMAR1GRM2GRM3KDM5APHF8 | |
| SCHEMBL9566036 | 0.74 | KDM5A (0.56) | SIGMAR1CYP1A2KDM5APHF8KDM2A | |
| SCHEMBL27620522 | 0.73 | GGT1 (0.46) | SIGMAR1GRM2GRM3CYP1A2EPHX1 | |
| Hydrochloric Acid SCHEMBL8745883 | 0.73 | GRM2 (0.42) | SIGMAR1GRM2GRM3KDM5APHF8 | |
| SCHEMBL6190677 | 0.73 | CYP1A2 (0.47) | SIGMAR1CYP1A2KDM5APHF8KDM2A | |
| Oxalic Acid SCHEMBL10697793 | 0.72 | SIGMAR1 (0.63) | SIGMAR1CYP1A2KDM5APHF8KDM2A | |
| SCHEMBL9133016 | 0.71 | KDM5A (0.57) | SIGMAR1CYP1A2KDM5APHF8KDM2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5378691-A | Amino acid derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-01-03 | — | — | US | disclosed |
| US-5215967-A | AMINOACID DERIVATIVES INHIBITING RENIN | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-06-01 | — | — | US | disclosed |
| EP-0418696-A2 | Derivatives of aminoacids | MERCK PATENT GmbH (DE) | 1991-03-27 | — | — | EP | disclosed |
| EP-0371390-A2 | Amino acid derivatives | MERCK PATENT GmbH (DE) | 1990-06-06 | — | — | EP | disclosed |
| EP-0369141-A1 | Aspartic protease inhibitors for the treatment of diseases caused by retroviruses | MERCK PATENT GmbH (DE) | 1990-05-23 | — | — | EP | disclosed |
| EP-0342325-A2 | Renin-inhibiting amino acid derivatives | MERCK PATENT GmbH (DE) | 1989-11-23 | — | — | EP | disclosed |
| EP-0337334-A2 | Renin-inhibiting amino acid derivatives | MERCK PATENT GmbH (DE) | 1989-10-18 | — | — | EP | disclosed |
| EP-0330925-A2 | Renin-inhibiting amino acid derivatives | MERCK PATENT GmbH (DE) | 1989-09-06 | — | — | EP | disclosed |
| EP-0328978-A2 | Renin-inhibiting amino acid derivatives | MERCK PATENT GmbH (DE) | 1989-08-23 | — | — | EP | disclosed |
| US-4746649-A | Diamino acid derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1988-05-24 | — | — | US | disclosed |
| EP-0161588-A2 | Diamino acid derivatives | MERCK PATENT GmbH (DE) | 1985-11-21 | — | — | EP | disclosed |