Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | METAP2 | P50579 | 3/20 | 0.36 |
| ▸ | BMP1 | P13497 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7293215 | 1.00 | METAP1 (0.39) | METAP1ALDH1A1KDM4EMETAP2BMP1 | |
| SCHEMBL7275541 | 1.00 | METAP1 (0.39) | METAP1ALDH1A1KDM4EMETAP2BMP1 | |
| SCHEMBL7283117 | 0.85 | ALDH1A1 (0.39) | METAP1ALDH1A1KDM4EBMP1HPGD | |
| SCHEMBL7269414 | 0.85 | METAP2 (0.45) | METAP1KDM4EMETAP2HPGDSMN1; SMN2 | |
| SCHEMBL7269423 | 0.85 | METAP2 (0.45) | METAP1KDM4EMETAP2HPGDSMN1; SMN2 | |
| SCHEMBL7269427 | 0.85 | METAP2 (0.45) | METAP1KDM4EMETAP2HPGDSMN1; SMN2 | |
| SCHEMBL7269419 | 0.85 | METAP2 (0.45) | METAP1KDM4EMETAP2HPGDSMN1; SMN2 | |
| SCHEMBL7282960 | 0.80 | METAP2 (0.43) | METAP1KDM4EMETAP2HPGDSMN1; SMN2 | |
| SCHEMBL13724320 | 0.70 | METAP1 (0.58) | METAP1METAP2 | |
| SCHEMBL7295280 | 0.69 | SHBG (0.42) | ALDH1A1KDM4EHPGDSMN1; SMN2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5106835-A | Hypotensive agents | AMERICAN CYANAMID COMPANY (US) | 1992-04-21 | — | — | US | disclosed |
| EP-0376040-A2 | N-phosphinyl di-and tripeptides as renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1990-07-04 | — | — | EP | disclosed |
| EP-0376012-A2 | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1990-07-04 | — | — | EP | disclosed |