Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.39 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7281089 | 0.89 | MAPT (0.42) | MAPTTDP1KDM4ENPC1KMT2A | |
| SCHEMBL7285178 | 0.85 | ADRA1D (0.40) | MAPTTDP1KDM4ENPC1KMT2A | |
| SCHEMBL7274544 | 0.84 | MAPT (0.39) | MAPTTDP1KDM4ENPC1KMT2A | |
| SCHEMBL7279479 | 0.82 | MAPT (0.36) | MAPTTDP1KDM4ENPC1KMT2A | |
| SCHEMBL7275324 | 0.77 | CHRNB4 (0.39) | NPC1KMT2A | |
| SCHEMBL7283442 | 0.76 | GAA (0.39) | TDP1NPC1KMT2A | |
| SCHEMBL7274916 | 0.74 | DRD2 (0.41) | MAPT | |
| SCHEMBL7283123 | 0.72 | TEAD3 (0.42) | MAPTKMT2A | |
| SCHEMBL7272672 | 0.70 | ALDH1A1 (0.39) | MAPTKMT2A | |
| SCHEMBL7276128 | 0.69 | LTA4H (0.46) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5591769-A | PYRROLIDINE DERIVATIVES; ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1997-01-07 | — | — | US | disclosed |
| US-5541343-A | ANTIAGGLOMERANTS FOR CELLS OR ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |
| EP-0483667-A2 | Cyclic imino derivatives, process for their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1992-05-06 | — | — | EP | disclosed |